Actively Recruiting
PErsonalized TReatment for Endometrial Carcinoma
Led by University of Helsinki · Updated on 2024-12-06
300
Participants Needed
1
Research Sites
359 weeks
Total Duration
On this page
Sponsors
U
University of Helsinki
Lead Sponsor
T
Turku University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare the efficacy of adjuvant therapies in women with stage I-II molecular integrated high-intermediate or high-risk endometrial carcinoma. Specifically, the invesigators want to compare: * Chemotherapy vs. chemoradiotherapy in p53 abn subtype and nonendometrioid carcinomas. * Vaginal brachytherapy vs. whole pelvic radiotherapy in the MMR-D molecular subgroup. * Vaginal brachytherapy vs. whole pelvic radiotherapy in the NSMP molecular subgroup.
CONDITIONS
Official Title
PErsonalized TReatment for Endometrial Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 100 years
- WHO performance status 0 to 2
- Stage I-II molecular integrated high-intermediate or high-risk endometrial carcinoma
You will not qualify if you...
- Age less than 18 years or greater than 100 years
- WHO performance status greater than 2
- Uterine sarcoma
- A history of malignancy within 5 years
- Previous pelvic radiotherapy
- An interval greater than 30 days between surgery and start of chemotherapy or greater than 8 weeks between surgery and start of radiotherapy (longer intervals may be permitted with investigator's approval)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Helsinki University Hospital
Helsinki, Finland, 00290
Actively Recruiting
Research Team
M
Mikko Loukovaara
CONTACT
R
Ralf Bützow
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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