Actively Recruiting
Personalized Volume-deescalated Elective Nodal Irradiation in Oropharyngeal Head and Neck Squamous Cell Carcinoma
Led by University of Zurich · Updated on 2025-11-18
120
Participants Needed
5
Research Sites
264 weeks
Total Duration
On this page
Sponsors
U
University of Zurich
Lead Sponsor
I
Insel Gruppe AG, University Hospital Bern
Collaborating Sponsor
AI-Summary
What this Trial Is About
Multicentric prospective model-based de-escalation of the elective clinical target volumes (CTV) in radiotherapy of oropharyngeal carcinoma of all stages with the goal to reduce toxicity. The study investigates the feasibility of this approach as measured by the number of expected out-of-field recurrencies based on the individual patient's state of disease progression and risk factors
CONDITIONS
Official Title
Personalized Volume-deescalated Elective Nodal Irradiation in Oropharyngeal Head and Neck Squamous Cell Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with newly diagnosed squamous cell carcinoma of the oropharynx (tonsils, base of tongue, oropharyngeal walls, or epiglottis), stages T1-4, N0-3
- Planned treatment with definitive (chemo)radiotherapy including elective lymph node irradiation
- Age 18 years or older with no upper age limit
- ECOG performance score less than 3
- History and physical examination within 30 days before study enrollment by a head and neck surgeon or radiation oncologist
- FDG-PET scan prior to enrollment, or if not possible, a contrast-enhanced MRI scan
- Ability and willingness to provide informed consent
You will not qualify if you...
- Presence of primary tumors extending clearly beyond the oropharynx into the oral cavity, nasopharynx, or hypopharynx
- Detection of distant metastases
- Previous surgery, chemotherapy, or radiotherapy for other head and neck cancers
- Previous surgery in the head and neck region affecting the cervical lymphatic system (except diagnostic lymph node dissection before treatment)
- Synchronous or prior malignancies except for certain treated cancers with defined disease-free intervals
- Pregnancy or breastfeeding
- Severe mental or psychological disorders affecting decision-making or consent ability
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Zurich University Hospital
Zurich, Canton of Zurich, Switzerland, 8091
Actively Recruiting
2
Cantonal Hospital Aarau
Aarau, Switzerland
Actively Recruiting
3
Ospedale Regionale di Bellinzona
Bellinzona, Switzerland
Actively Recruiting
4
Inselspital Bern
Bern, Switzerland
Actively Recruiting
5
Hôpitaux universitaires de Genève
Geneva, Switzerland
Actively Recruiting
Research Team
P
Panagiotis Balermpas, MD
CONTACT
D
Debra Lauer, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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