Actively Recruiting
Pesticides and Infertility: Oxidative Stress Via Circulating Cell-free DNA and Gut/Genital Microbiome Signatures in Women With Endometriosis
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2026-03-13
160
Participants Needed
1
Research Sites
113 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This project PestiEndoMicro aims to provide an innovative approach, studying endometriosis under the genital and gut microbiota scope. To realize this project, the investigators are planning to dose cfDNA to assess the oxidative stress caused by endometriosis and study its epigenetics. At the same time, the investigators will take a pragmatic approach by assessing pesticide exposure in these patients and estimate the correlation between gut or genital dysbiosis and chemical agent exposure. Also, the investigators will take the initiative to use classic culture, qPCR techniques, and NGS to establish signatures in vaginal, endometrial and gut microbiota in patients with endometriosis. With these approaches, the goal is to gain more knowledge about endometriosis and optimize early diagnosis by establishing a signature in the genital and gut microbiota, but also by dosing the cfDNA. By doing so the investigators could open new opportunities to develop new therapeutic strategies for endometriosis.
CONDITIONS
Official Title
Pesticides and Infertility: Oxidative Stress Via Circulating Cell-free DNA and Gut/Genital Microbiome Signatures in Women With Endometriosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 to 43 with confirmed endometriosis grade 3 or 4 for the case group
- Women aged 18 to 43 with proven male infertility and no endometriosis for the control group
- Women not treated with antibiotics in the 3 months before inclusion
- Women not participating in any pharmacological study
- Women covered by national social security health insurance
- Women who have signed informed consent after reflection
You will not qualify if you...
- Women aged 44 or older
- Women who are overweight, obese, or anorexic
- Women taking antibiotics within 3 months before inclusion or in a drug study
- Women under anti-GnRH treatment, pregnant, or with chronic inflammatory diseases like Crohn's or PCOS
- Women without formal confirmation of endometriosis by specified tests
- Patients under guardianship, curatorship, or legal protection
- Women who have not signed or who withdraw informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
CHRU Amiens
Salouël, France
Actively Recruiting
Research Team
M
Moncef BENKHALIFA, Pr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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