Actively Recruiting
PET Detection of CCR2 in Human Atherosclerosis
Led by Washington University School of Medicine · Updated on 2025-08-01
100
Participants Needed
1
Research Sites
256 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
: Use of novel radio-pharmaceutical 64CUDOTA-ECL1i to evaluate arterial atherosclrosis
CONDITIONS
Official Title
PET Detection of CCR2 in Human Atherosclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Normal volunteers aged 18-40 years who do not smoke and have no history of diabetes, hypertension, or high cholesterol
- Patients aged 50-89 years with adequate nutrition, with or without smoking history, diabetes, hypertension, or high cholesterol
- Both asymptomatic and symptomatic patients with known carotid artery atherosclerosis greater than 70% who are scheduled for surgery
- Patients with advanced peripheral artery disease
You will not qualify if you...
- Unable to provide and sign informed consent
- Currently enrolled in another study
- Patients with type 1 diabetes or septic shock
- Receiving steroid therapy
- Recent history of heavy alcohol use (males more than 2 drinks per day, females more than 1 drink per day)
- Following extreme diets such as Atkins or South Beach diet
- Stage 4 chronic renal failure
- Unstable clinical condition as judged by the principal investigator
- Unable to tolerate 60 minutes lying on back with arms at sides
- Contraindications to MRI (e.g., pacemaker, brain aneurysm clips, shrapnel)
- Positive pregnancy test or currently breastfeeding
- Other conditions such as cancer or autoimmune/inflammatory diseases like rheumatoid arthritis or multiple sclerosis that increase CCR2 expression
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Washington University CCIR
St Louis, Missouri, United States, 63110
Actively Recruiting
Research Team
K
Kitty Harrison, BSN, RN
CONTACT
R
Robert Gropler, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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