Study on PET-Guided Surgery for Adults With High-Grade Gliomas to Improve Survival Outcomes

What this Trial Is About

Glioblastoma GBM is the most common and aggressive primary brain tumor in adults, with a poor outlook despite current treatments. Researchers are studying whether using 18F-DOPA PET imaging to guide brain tumor surgery can improve survival by targeting tumor areas beyond those seen on standard MRI scans. This study compares outcomes between patients who have PET-guided tumor removal and those who have surgery guided only by conventional MRI. Patients with newly diagnosed, high-grade gliomas in the upper brain will have preoperative PET and MRI scans. Surgeons aim for maximal safe tumor removal using these images, collecting tissue samples from different tumor regions for detailed analysis. After surgery, patients undergo follow-up MRI and PET scans to assess how much tumor was removed and to categorize them based on PET-guided resection status. The study lasts four years and includes phases for preparation, recruitment, data analysis, and sharing results. During the study, participants will have multiple imaging tests, surgery with tissue sampling, and regular follow-up visits to track tumor progression and survival. Researchers will analyze survival times, molecular tumor features, and imaging data to understand the benefits of PET-guided surgery. Safety and neurological function will be monitored throughout, with data collected up to five years after surgery.

PET-Guided Resection in High-Grade Gliomas