Actively Recruiting
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Led by National Institute of Mental Health (NIMH) · Updated on 2026-03-03
60
Participants Needed
1
Research Sites
192 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from COVID-19 have long-term symptoms that affect the brain. These include headaches; loss of taste and smell; sleep problems; thinking problems; depression; and anxiety. Researchers want to know if a tracer (a substance that is injected into a person s body before an imaging scan) can help identify inflammation in people with these brain disorders. Objective: To see if a radioactive tracer (\[11C\]PS13) can highlight brain inflammation in those who had COVID-19 but still have symptoms that affect the brain. Eligibility: Adults aged 18 to 70 years with post COVID-19 brain disorders who are enrolled in protocol 000089 or 000711. Healthy volunteers are also needed. Design: Participants will have up to 5 clinic visits. Participants will be screened. They will have blood tests and a test of their heart function. They will have imaging scans: Magnetic resonance imaging (MRI): They will lie on a table that slides into a metal tube. Pictures will be taken of the brain. Positron emission tomography (PET): A needle attached to a thin tube will be inserted into a vein in the arm. The tracer will be injected through the tube. Another needle attached to a thin tube will be inserted into the wrist or inside of the elbow of the other arm to draw blood. They will lie still on a bed while a machine captures images of their brain. The scan will last about 2 hours. Study involvement is 11 to 14 weeks....
CONDITIONS
Official Title
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 70 years
- In good general health based on medical history and physical exam
- Able to understand and consent to all required tests and examinations
- For Neuro-PASC participants: enrolled in specific protocols and diagnosed with Neuro-PASC
- Have adequate ulnar collateral blood flow and no metal or foreign objects in both wrists
- Agree to follow lifestyle considerations
- For healthy volunteers: aged 18 to 70 years, able to consent, good general health with no cognitive impairment
- No active SARS-CoV-2 infection; at least six weeks since symptom onset with no fever for at least one week
- Report at least one prior SARS-CoV-2 infection
- Enrolled in specified healthy volunteer protocols
- Have adequate ulnar collateral blood flow and no metal or foreign objects in both wrists
- Agree to follow lifestyle considerations
You will not qualify if you...
- Clinically significant abnormalities on EKG or laboratory tests, including elevated creatinine (>1.3 mg/dL)
- Use of NSAIDs within two weeks prior to PET scan
- Use of corticosteroids or immunosuppressants within one month prior to PET scan
- Substance use disorder or alcohol use disorder that impairs daily life
- Unstable medical conditions making participation unsafe
- Unable to travel to NIH
- Recent exposure to research-related radiation exceeding limits
- Inability to lie flat and still for at least two hours (including claustrophobia or weight limits)
- Unable to have MRI due to implanted devices or metal fragments
- Pregnancy or breastfeeding
- HIV infection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
T
Tara N Turon, C.R.N.P.
CONTACT
R
Robert B Innis, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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