Actively Recruiting
PET Imaging Targeting Granzyme B to Predict Immunotherapy Response in Diffuse Large B-Cell Lymphoma An Observational Study
Led by Ruijin Hospital · Updated on 2025-01-01
150
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how PET imaging that targets granzyme B can predict how well immunotherapy works for patients with diffuse large B-cell lymphoma (DLBCL). This study focuses on patients receiving immunotherapy treatments such as CAR-T, Glofitamab, or iR2. The goal is to see if PET scans can help forecast treatment outcomes. Participants will undergo PET scans using 68Ga-grazytracer both before starting immunotherapy and after completing one course of treatment. Medical records will be created for each participant, including their basic information, contact details, and medical history. The study tracks uptake values from these scans at baseline and two weeks after treatment. During the study, researchers will collect and record participant data, perform PET imaging assessments, and monitor treatment effects. They will measure standardized uptake values and the ability of PET scans to predict immunotherapy success. The information gathered will help evaluate the imaging method's usefulness in managing DLBCL patients.
CONDITIONS
Official Title
PET Imaging Targeting Granzyme B Predicts Immunotherapy Efficacy in Diffuse Large B-cell Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathologic diagnosis of DLBCL
- General condition is good with expected survival greater than six months
- Signed and dated informed consent form
You will not qualify if you...
- Presence of other malignant tumors
- Serious medical conditions deemed unsuitable by the investigator
- Pregnant or breastfeeding women, and women at risk of pregnancy
- Poor compliance
AI-Screening
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Trial Site Locations
Total: 1 location
1
Ruijin Hospital Affiliated to Shanghai Jiao Tong University Medical School
Shanghai, China
Actively Recruiting
Research Team
X
Xinyi Zhu
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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