Imaging Tau Protein in Frontotemporal Lobar Degeneration and Atypical Alzheimers Disease Using the PET Tracer 18F-PI-2620

What this Trial Is About

Researchers are comparing brain scans using the 18F-PI-2620 tracer in people with frontotemporal lobar degeneration FTLD, non-amnestic Alzheimers disease naAD, and healthy adults. This study builds upon a larger observational research project UNICORN that collects brain imaging, clinical assessments, and genetic data to better understand neurodegenerative diseases. Participants include various groups diagnosed by neurologists, aiming to see how tau protein accumulates in different conditions. Participants undergo a baseline PETCT brain scan with the 18F-PI-2620 tracer. If funding allows, some may return for additional scans 12 to 24 months apart to monitor changes over time. Seven groups are studied, including healthy adults, different types of FTLD, and Alzheimers subtypes. Each participant will have at least one PET scan to assess tau accumulation in the brain. During the study, participants continue their involvement in the UNICORN observational study, which includes periodic MRI scans and neuropsychological testing. Researchers measure brain tau levels using PET scan results and track cognitive and functional abilities. Safety is monitored, and participants provide informed consent. The study plans to collect data over about six years, with ongoing assessments of brain imaging and clinical status.

PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620