Actively Recruiting
PET Imaging of Vaso-Occlusive Crisis (VOC) in SCD
Led by Enrico Novelli · Updated on 2025-05-07
20
Participants Needed
1
Research Sites
268 weeks
Total Duration
On this page
Sponsors
E
Enrico Novelli
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to find objective biomarkers of vaso-occlusion (blood vessel blockage) in people with SCD. Using information from earlier studies and work being done, researchers have developed a strategy to image VOC, using positron emission tomography (PET). The ability to see and measure VOC in SCD patients can help patient care, by showing when and how a VOC is occurring or going to occur. Studying this method will also help in future drug research, as it will allow researchers to deliver promising new medications that target hyper-adhesion and sickling in people with SCD.
CONDITIONS
Official Title
PET Imaging of Vaso-Occlusive Crisis (VOC) in SCD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a confirmed diagnosis of Sickle Cell Disease (HbSS, SC, S/β-thalassemia, SD, SE, SO) by hemoglobin electrophoresis or High Performance Liquid Chromatography (HPLC)
- Aged 18 years or older
- Able to understand and provide informed consent
- If taking hydroxyurea, L-glutamine, crizanlizumab, voxelotor, or erythropoietin stimulating agents, must have been on the medication for at least 12 weeks before screening and plan to continue the same dose and schedule during the study
- Experienced at least 2 vaso-occlusive crises leading to healthcare visits within the 12 months before screening
You will not qualify if you...
- Have an active malignancy
- Are currently pregnant or breastfeeding
- Participating in a chronic transfusion program or planning an exchange transfusion during the study (episodic transfusions for worsened anemia or VOC are allowed)
- Received active treatment in another investigational trial within 30 days or 5 half-lives of that agent before screening, or plan to join another investigational drug trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UPMC
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
J
Jude Jonassaint, RN
CONTACT
L
Leticia Candra, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
SCREENING
Number of Arms
2
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