Actively Recruiting
PET/MR Multimodal Quantitative Analysis of CBF and CMRGlc in Cerebral Ischemia
Led by Xuanwu Hospital, Beijing · Updated on 2025-11-20
200
Participants Needed
1
Research Sites
161 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Research Purpose: This project focuses on clinical research issues in the diagnosis, treatment, and evaluation of patients with cephalic and carotid atherosclerosis. Through multimodal imaging technology, it aims to optimize non-invasive quantitative algorithm models for cerebral blood flow and cerebral metabolism, explore new imaging markers, and investigate quantitative indicators of cerebral blood flow and metabolism for the diagnosis, treatment, and evaluation of patients with cephalic and carotid atherosclerosis undergoing drug therapy or surgical treatment. Research Design: 1. Study Type: Observational study 2. Study Subjects: In accordance with the \*Chinese Clinical Management Guidelines for Cerebrovascular Diseases (2nd Edition)\*, patients with cephalic and carotid atherosclerotic stenosis admitted to the department of neurosurgery will be enrolled. Data collection time points are at enrollment, 6-month follow-up, and 12-month follow-up. 3. Sample Size: 200 patients with cephalic and carotid atherosclerotic stenosis. 4. Observation Indicators: Distribution patterns of cerebral blood flow and metabolic reduction areas in patients; correlation analysis between blood flow, metabolic values and clinical scores. 5. Statistical Analysis Methods: Statistical analysis will be performed using Statistical Package for the Social Sciences (SPSS) version 21.0. All statistical results will be expressed as mean ± standard deviation. First, the Shapiro-Wilk test will be used to assess normal distribution. Under the premise of normal distribution, paired t-test will be used to compare blood flow and metabolic values between the lesion area and the contralateral area of patients, as well as to compare changes in blood flow and metabolism of patients at different time points. Pearson correlation analysis will be used to analyze the relationship between blood flow/metabolic parameters and clinical neurological function scores. The Mann-Whitney U test will be used to analyze variables with non-normal distribution. A P value \< 0.05 will be considered statistically significant.
CONDITIONS
Official Title
PET/MR Multimodal Quantitative Analysis of CBF and CMRGlc in Cerebral Ischemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed by angiography with unilateral anterior circulation carotid artery stenosis with more than 70% diameter reduction
- Contralateral anterior circulation and bilateral posterior circulation stenosis less than or equal to 50%
- History of transient ischemic attack or ischemic stroke in the affected vessel area within past 12 months, with last onset more than 3 weeks ago
- MRI shows no new infarct lesions in the brain
- No infarct lesions in the previous pontine area
- Participant and informants can complete examinations and follow-ups
- Signed informed consent by participant or authorized representative
You will not qualify if you...
- Poor image quality due to head movement or other scanning issues
- Presence of neurological diseases causing brain dysfunction such as depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal pressure hydrocephalus
- Presence of systemic diseases causing cognitive impairment including hepatic insufficiency, renal insufficiency, thyroid dysfunction, severe anemia, vitamin deficiencies, infections like syphilis or HIV, alcohol or drug abuse
- Other known diseases causing cognitive impairment
- Severe visual or hearing impairment, claustrophobia, or conditions preventing MRI cooperation
- Diseases preventing cooperation with cognitive examinations
- Refusal to sign informed consent at baseline
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Xuanwu Hospitail, Capital Medical University
Beijing, China
Actively Recruiting
Research Team
B
Bixiao Cui
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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