Non-Invasive PETMR Imaging to Measure Brain Blood Flow and Glucose Metabolism in Men Aged 18 to 80 with Carotid Artery Narrowing and Stroke

What this Trial Is About

Researchers are studying patients with cephalic and carotid atherosclerosis to improve diagnosis, treatment, and evaluation using advanced multimodal imaging techniques. This observational study focuses on optimizing non-invasive methods to measure cerebral blood flow and metabolism, exploring new imaging markers, and analyzing quantitative indicators for patients undergoing drug or surgical treatments. The study follows guidelines for cerebrovascular disease management and aims to understand blood flow and metabolic patterns related to neurological function. Participants diagnosed with significant unilateral carotid artery stenosis who have experienced a transient ischemic attack or ischemic stroke within the past year will be observed. The study collects data at enrollment, with follow-ups at 6 and 12 months. Imaging and clinical assessments are used to analyze changes in cerebral blood flow and glucose metabolism over time. Statistical methods will evaluate the relationship between these imaging findings and clinical neurological scores. During the study, participants will undergo imaging scans and clinical evaluations at specified intervals to measure cerebral blood flow and metabolic rates. Researchers will analyze these measurements alongside neurological function scores to assess disease progression and treatment impact. The primary outcomes focus on changes in cerebral blood flow and glucose metabolism six months after treatment. The study is expected to last until August 2028, with ongoing monitoring and data collection at multiple time points.

PET/MR Multimodal Quantitative Analysis of CBF and CMRGlc in Cerebral Ischemia