Actively Recruiting
PET/MR Multimodal Quantitative Imaging of Cerebral Ischemia With CBF and CMRGlc Assessment in Cephalo-Carotid Atherosclerosis
Led by Xuanwu Hospital, Beijing · Updated on 2025-11-20
200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients with cephalic and carotid atherosclerosis to improve diagnosis, treatment, and evaluation using advanced multimodal imaging techniques. This observational study focuses on optimizing non-invasive methods to measure cerebral blood flow and metabolism, exploring new imaging markers, and analyzing quantitative indicators for patients undergoing drug or surgical treatments. The study follows guidelines for cerebrovascular disease management and aims to understand blood flow and metabolic patterns related to neurological function. Participants diagnosed with significant unilateral carotid artery stenosis who have experienced a transient ischemic attack or ischemic stroke within the past year will be observed. The study collects data at enrollment, with follow-ups at 6 and 12 months. Imaging and clinical assessments are used to analyze changes in cerebral blood flow and glucose metabolism over time. Statistical methods will evaluate the relationship between these imaging findings and clinical neurological scores. During the study, participants will undergo imaging scans and clinical evaluations at specified intervals to measure cerebral blood flow and metabolic rates. Researchers will analyze these measurements alongside neurological function scores to assess disease progression and treatment impact. The primary outcomes focus on changes in cerebral blood flow and glucose metabolism six months after treatment. The study is expected to last until August 2028, with ongoing monitoring and data collection at multiple time points.
CONDITIONS
Brief Title
PET/MR Multimodal Quantitative Analysis of CBF and CMRGlc in Cerebral Ischemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with unilateral anterior circulation carotid artery stenosis with more than 70% diameter reduction
- Contralateral anterior and bilateral posterior circulation stenosis not exceeding 50% diameter reduction
- Experienced a transient ischemic attack or ischemic stroke in the diseased vessel area within the past 12 months, with onset more than 3 weeks ago
- MRI shows no new infarct lesions in the skull
- No infarct lesion in the previous pontine area
- Able to complete relevant examinations and follow-ups
- Signed informed consent by participant or authorized representative
You will not qualify if you...
- Poor image quality due to head movement or other scanning issues
- Other neurological diseases causing brain dysfunction (e.g., depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal pressure hydrocephalus)
- Other systemic diseases causing cognitive impairment (e.g., hepatic or renal insufficiency, thyroid dysfunction, severe anemia, vitamin deficiencies, specific infections, alcohol or drug abuse)
- Other known diseases causing cognitive impairment
- Severe visual or hearing impairment, claustrophobia, or conditions preventing MRI cooperation
- Diseases preventing cooperation with cognitive examinations
- Refusal to sign informed consent at baseline
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Baseline and 6 months
Participants undergo PET and MR imaging to quantitatively assess cerebral blood flow and cerebral metabolic rate of glucose.
2 visits (in-person)
Duration - 6 months
Participants are observed over 6 months to monitor changes in cerebral blood flow and metabolism following their condition.
1 visit at 6 months (in-person)
Trial Site Locations
Total: 1 location
1
Xuanwu Hospitail, Capital Medical University
Beijing, China
Actively Recruiting
Research Team
B
Bixiao Cui
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here