Actively Recruiting
PET/MR Pre- and Post Radiotherapy for Cardiopulmonary Dysfunction Evaluation
Led by University Health Network, Toronto · Updated on 2025-12-10
40
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Radiotherapy (RT) is a well-known and established therapy or adjuvant therapy for the treatment of thoracic cancer It uses a high energy radiation from x-rays, gamma rays and other charged particles that assist in damaging the cancer DNA. PET/MR as imaging biomarkers for cardiopulmonary dysfunction with a focus on Pulmonary hypertension (PH). Despite the measures taken to reduce the total radiation dose and to limit the radiation to normal tissues, there is evidence of transient or permanent radiotherapy induced myocardial and pulmonary dysfunction leading to PH in patients who receive radiotherapy above a certain threshold of received dose. To be able to Demonstrate correlation of combined PET/MR and plasma metabolomics markers in patients at risk of developing cardiopulmonary disfunction after RT.
CONDITIONS
Official Title
PET/MR Pre- and Post Radiotherapy for Cardiopulmonary Dysfunction Evaluation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Biopsy or clinically confirmed thoracic cancer planned for radiotherapy or chemoradiotherapy
- Planned radiotherapy with incidental cardiac radiation dose of at least 25 Gy
- Negative urine or serum pregnancy test within two weeks before imaging for women of childbearing age
- Ability to provide written informed consent for imaging and blood sampling
You will not qualify if you...
- Contraindications to MRI according to institutional guidelines
- Contraindications to gadolinium contrast injection as per institutional guidelines
- Inability to lie flat on back for at least 45 minutes
- Pregnancy or breastfeeding
- Known allergy to 18F-fluorodeoxyglucose (18F-FDG)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Health Network
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
Research Team
P
Patrick Veit-Haibach, MD
CONTACT
A
Andrew Hope, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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