Actively Recruiting
Pharmacogenetic Panel to Prevent Adverse Drug Reactions in Daily Primary Care Practice:
Led by Mayo Clinic · Updated on 2025-10-14
66
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine whether the implementation of pre-emptive pharmacogenomic (PGx) testing of a panel of clinically relevant PGx markers, to guide the dose and drug selection for 39 commonly prescribed drugs, will result in an overall reduction in the number of clinically relevant drug-genotype associated ADRs which are causally related to the initial drug of inclusion (referred to as 'index drug').
CONDITIONS
Official Title
Pharmacogenetic Panel to Prevent Adverse Drug Reactions in Daily Primary Care Practice:
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant is 18 years or older
- Receiving a first prescription for a drug included in the study's list with no prescription for that drug in the past 12 months
- Willing and able to participate and be followed for 48 weeks
- Able to provide a saliva sample
- Has signed informed consent
- Has computer access demonstrated by active use of a patient portal or email
You will not qualify if you...
- Previous pharmacogenomic testing including genes in the study panel (investigational arm only)
- Pregnant or lactating
- Life expectancy less than three months or receiving hospice care
- Planned treatment with the index drug for less than seven consecutive days
- Currently an inpatient
- Unable to provide consent
- Unwilling to participate
- No permanent address
- No current primary care provider
- Deemed unsuitable by study coordinator and clinical team
- Diagnosis of stage 4 or 5 chronic kidney disease or receiving dialysis
- Advanced liver failure (Child-Pugh C) or liver cirrhosis
- History of liver transplant or allogeneic hematopoietic stem cell transplant
- Insufficient DNA sample requiring retesting
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55902
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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