Actively Recruiting
Pharmacogenetics of Leflunomide in the Management of Rheumatoid Arthritis
Led by Foundation University Islamabad · Updated on 2026-02-05
110
Participants Needed
2
Research Sites
108 weeks
Total Duration
On this page
Sponsors
F
Foundation University Islamabad
Lead Sponsor
S
Shifa Tameer-e-Millat University
Collaborating Sponsor
AI-Summary
What this Trial Is About
1. Patients taking leflunomide as the only disease-modifying anti-rheumatic drug (DMARD) will be recruited after consent. 2. Blood sample for DNA extraction will be taken The patient will be followed up till two visits 3 months apart, and efficacy and toxicity will be checked using DAS28, ultrasonography, and blood tests for ESR, CRP, anti-CCP, liver function tests, etc. The data form for toxicity will be filled. 3. DNA will be extracted in the laboratory, and SNP will be identified. 4. The efficacy and toxicity data will be studied against the SNPs found 5. An algorithm will be constructed for Pakistani RA patients taking leflunomide.
CONDITIONS
Official Title
Pharmacogenetics of Leflunomide in the Management of Rheumatoid Arthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must meet the revised ACR/EULAR criteria for rheumatoid arthritis at baseline
- Pakistani individuals
- Aged between 20 and 75 years
- New cases started on leflunomide or those taking it for less than one month with available clinical and biochemical data
You will not qualify if you...
- Patients not willing to participate or who do not provide consent
- Patients under 20 years of age
- Non-Pakistani individuals
- Taking another DMARD simultaneously
- Having compromised kidney or liver function
- Cognitive impairment or neurological disease
- Pregnant or lactating women
- Patients with inflammatory bowel disease or irritable bowel syndrome
- Patients with active infections
- Patients who do not complete 3 months of leflunomide therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Shifa International Hospital
Islamabad, Punjab Province, Pakistan, 44000
Completed
2
Fauji Foundation Hospital, Rawalpindi
Rawalpindi, Punjab Province, Pakistan, 46000
Actively Recruiting
Research Team
D
Dr. Zarafshan Bader, MPhil, MBBS
CONTACT
D
Dr Abida Shaheen, PHD, MBBS, FAIMER FELLOW
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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