Actively Recruiting
Pharmacogenomics of Selective Serotonin Reuptake Inhibitor (SSRI)-Induced Behavioural Activation
Led by University of Manitoba · Updated on 2025-09-08
160
Participants Needed
2
Research Sites
304 weeks
Total Duration
On this page
Sponsors
U
University of Manitoba
Lead Sponsor
H
Health Sciences Centre Foundation, Manitoba
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to identify and validate a panel of genetic markers associated with selective serotonin reuptake inhibitors (SSRI)-induced behavioural activation in children and youth with major depressive disorder (MDD), anxiety disorders, or obsessive-compulsive disorder (OCD) that could be used clinically to reduce the incidence of this adverse event and improve health outcomes.
CONDITIONS
Official Title
Pharmacogenomics of Selective Serotonin Reuptake Inhibitor (SSRI)-Induced Behavioural Activation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Resident of Manitoba
- Age between 6 and 24 years
- Diagnosis of major depressive disorder (MDD), anxiety disorder, or obsessive-compulsive disorder (OCD)
- Current or past history of selective serotonin reuptake inhibitor (SSRI) therapy such as Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Sertraline, or Paroxetine
- For cases: experienced behavioural side effects after taking an SSRI that resolved after reducing the dose or stopping the drug
- For controls: did not experience any side effects after taking an SSRI for eight continuous weeks
You will not qualify if you...
- Inability of parent/legal guardian/mature minors to give informed consent
- Inability of the child (6 to 13 years) to give informed assent
- Unwillingness of the child to provide a saliva sample for genetic analysis
- Current, past, or suspected diagnosis of attention deficit hyperactivity disorder (combined or hyperactive type), oppositional defiant disorder, conduct disorder, bipolar disorder, psychotic disorder, pervasive developmental disorder
- History of liver or bone marrow (hematopoietic cell) transplant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Shared Health Facilities
Winnipeg, Manitoba, Canada, R3C 3H8
Actively Recruiting
2
University of Manitoba College of Pharmacy
Winnipeg, Manitoba, Canada, R3E 0T5
Actively Recruiting
Research Team
A
Abdullah A Maruf, BPharm, MPharm, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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