Actively Recruiting
Pharmacokinetic Modeling of Methadone
Led by University Hospital, Montpellier · Updated on 2024-11-21
100
Participants Needed
1
Research Sites
75 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The management of patients with opioid addiction is a challenge insofar as many distractors or variability factors can interfere with the control of the addiction, whether they are psychological, psychiatric, environmental, pharmacokinetic or pharmacodynamic. Understanding this variability is potentially to be able to adjust a priori a dosage and to identify the factors of clinical response. Few population pharmacokinetic models exist for methadone and they generally concern the management of pain in palliative care patients or the management of opioid withdrawal syndrome in neonates. The hypothesis is therefore that the creation of such a model would make it possible to reduce patients' withdrawal periods, to set a target for plasma concentrations with a view to reducing dosages, and to empower the patient in his choice to monitor blood concentrations facilitated by a minimally invasive sampling device.
CONDITIONS
Official Title
Pharmacokinetic Modeling of Methadone
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Receiving methadone at the same dose for at least 7 days
- Hospitalized for withdrawal in the addictology department of La Colombière or attending consultation at the drug addiction treatment unit
- Able and willing to undergo 24 hours of monitoring
You will not qualify if you...
- Patients with weakened veins preventing blood sampling
- Unable to receive or understand information about the study
- Within an exclusion period from a previous study
- Adults protected by law or under guardianship
- Not affiliated with the French social security system
- Unable to give written informed consent
- Pregnant or breastfeeding women
- Under 18 years old
- Patients under court protection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHU de Montpellier
Montpellier, France
Actively Recruiting
Research Team
Y
Yoann Cazaubon, phD,pharmD
CONTACT
H
Hélène Donnadieu-Rigole, phD,MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
1
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