Actively Recruiting
Pharmacokinetic Study of Skeletal Muscle Area-based Paclitaxel Infusion in Patients With Cancer
Led by University of Michigan Rogel Cancer Center · Updated on 2026-03-06
22
Participants Needed
1
Research Sites
218 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of this pharmacokinetics study is to compare the maximum concentration level of paclitaxel in patients with low/sarcopenic skeletal muscle area (SMA), at the end of a 2-3 hour paclitaxel infusion, to the maximum level in patients with normal SMA at the end of a standard 1-hour infusion with the goal of determining whether lengthening the infusion in patients with low/sarcopenic SMA normalizes the levels to those of patients with normal SMA.
CONDITIONS
Official Title
Pharmacokinetic Study of Skeletal Muscle Area-based Paclitaxel Infusion in Patients With Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Planned paclitaxel 80 mg/m^2, 1-hour infusion
- Evaluable CT, PET-CT, or MRI scan of chest, abdomen, or pelvis within 1 year
- Female
- Age 18 years or older
- Adequate organ function to receive paclitaxel as per protocol
- Ability and willingness to sign informed consent
You will not qualify if you...
- Use of moderate or strong CYP2C8 inducers or inhibitors (e.g., rifampin, clopidogrel)
- History of hypersensitivity to paclitaxel or its components preventing standard treatment
- Pregnant or nursing
- Receiving paclitaxel at a different dose or infusion rate than 80 mg/m^2 over 1 hour due to toxicity or other reasons
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
Research Team
C
Cancer AnswerLine
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here