Actively Recruiting
Pharmacokinetics of Didehydro-LSD (DDH-LSD) Compared With LSD
Led by University Hospital, Basel, Switzerland · Updated on 2026-03-10
24
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study investigates DDH-LSD, a novel LSD-like compound expected to have a shorter duration of action than LSD. In healthy volunteers, pharmacokinetics, safety, and subjective effects, will be assessed and compare with LSD in a controlled cross-over study.
CONDITIONS
Official Title
Pharmacokinetics of Didehydro-LSD (DDH-LSD) Compared With LSD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 25 and 65 years old
- Sufficient understanding of the German language
- Understanding of procedures and risks associated with the study
- Willing to adhere to the protocol and sign the consent form
- Willing to refrain from consuming illicit psychoactive substances during the study
- Abstain from xanthine-based liquids from the evenings prior to and during study sessions
- Willing not to operate heavy machinery within 48 hours after substance administration
- Willing to use effective contraceptive measures throughout study participation
- Body mass index between 18 and 32 kg/m2
You will not qualify if you...
- Having any chronic or acute medical condition
- Current or previous major psychiatric disorder
- Psychotic or bipolar disorder in first-degree relatives
- Hypertension (SBP >140/90 mmHg) or hypotension (SBP <85 mmHg)
- Use of hallucinogenic substances (excluding cannabis) more than 20 times or within the last two months
- Pregnancy or breastfeeding
- Participation in another clinical trial currently or within the last 30 days
- Use of medications that may interfere with study medication effects
- Smoking more than 10 cigarettes per day
- Consuming more than 20 alcoholic drinks per week
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Basel
Basel, Switzerland, 4031
Actively Recruiting
Research Team
M
Matthias Liechti, Prof. MD
CONTACT
M
Mélusine Humbert-Droz
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
3
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