Actively Recruiting

Phase 2
Age: 12Years - 17Years
All Genders
NCT07213973

Pharmacokinetics, Safety, and Efficacy of Povorcitinib in Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa

Led by Incyte Corporation · Updated on 2026-05-08

40

Participants Needed

27

Research Sites

111 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this study is to evaluate the pharmacokinetics, safety, and efficacy of povorcitinib in adolescent participants with moderate to severe hidradenitis suppurativa over a 54-week open-label treatment period.

CONDITIONS

Official Title

Pharmacokinetics, Safety, and Efficacy of Povorcitinib in Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa

Who Can Participate

Age: 12Years - 17Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged 6 12 to < 18 years at the time of informed consent/assent signing
  • Body weight 6 30 kg at both screening and baseline visits
  • Diagnosis of moderate to severe hidradenitis suppurativa for at least 3 months before screening
  • Total abscess and inflammatory nodule count of at least 5 at screening and baseline
  • Hidradenitis suppurativa lesions at refined Hurley Stage IB, IC, IIB, IIC, or III at screening and baseline
  • History of inadequate response to at least 3 months of one conventional systemic therapy (oral antibiotic or biologic) or intolerance/contraindication to such therapy
  • Agreement to use contraception
  • Willingness and ability to follow study procedures
  • Further inclusion criteria apply
Not Eligible

You will not qualify if you...

  • More than 20 draining tunnels (fistulas) at screening or baseline
  • Women who are pregnant, breastfeeding, or considering pregnancy
  • History of thrombocytopenia, coagulopathy, platelet dysfunction, Q-wave interval abnormalities, certain infections, cancer, lymphoproliferative disorders, or other medical conditions per investigator discretion
  • Laboratory test results outside protocol-defined ranges
  • Further exclusion criteria apply

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 27 locations

1

University of Alabama At Birmingham

Birmingham, Alabama, United States, 35233

Not Yet Recruiting

2

Medical Dermatology Specialists Phoenix

Phoenix, Arizona, United States, 85006

Actively Recruiting

3

Saguaro Dermatology

Phoenix, Arizona, United States, 85008

Actively Recruiting

4

Uconn Health

Farmington, Connecticut, United States, 06030

Not Yet Recruiting

5

University of Miami Miller School of Medicine

Miami, Florida, United States, 33136

Actively Recruiting

6

Skin Research of South Florida, Llc

Miami, Florida, United States, 33173

Actively Recruiting

7

Trueblue Clinical Research

Tampa, Florida, United States, 33609

Actively Recruiting

8

Advanced Medical Research Pc

Sandy Springs, Georgia, United States, 30328

Actively Recruiting

9

Endeavor Health Medical Group

Skokie, Illinois, United States, 60077

Actively Recruiting

10

Dermatology Skin Cancer Center Leawood

Leawood, Kansas, United States, 66211

Actively Recruiting

11

Equity Medical

Bowling Green, Kentucky, United States, 42104

Actively Recruiting

12

Johns Hopkins Oncology Center

Baltimore, Maryland, United States, 21287

Actively Recruiting

13

Boston Childrens Hospital

Boston, Massachusetts, United States, 02115

Not Yet Recruiting

14

Oakland Hills Dermatology Pc

Auburn Hills, Michigan, United States, 48326

Actively Recruiting

15

Wayne State University Physician Group Dermatology

Detroit, Michigan, United States, 48201

Actively Recruiting

16

Revival Research Institute, Llc Troy

Troy, Michigan, United States, 48084

Actively Recruiting

17

Washington University

St Louis, Missouri, United States, 63110

Actively Recruiting

18

Boeson Research Missoula 2825 Fort Missoula Rd

Missoula, Montana, United States, 59804

Actively Recruiting

19

University of New Mexico Hospital

Albuquerque, New Mexico, United States, 87102

Actively Recruiting

20

Geisinger Medical Center

Danville, Pennsylvania, United States, 17822

Not Yet Recruiting

21

Bellaire Dermatology Associates Bda

Bellaire, Texas, United States, 77401

Actively Recruiting

22

Texas Dermatology Research Center

Dallas, Texas, United States, 75246

Actively Recruiting

23

Jordan Valley Dermatology Center

South Jordan, Utah, United States, 84095

Actively Recruiting

24

Dermcare Clinic

Mississauga, Ontario, Canada, L4W 0C2

Actively Recruiting

25

York Dermatology Center

Richmond Hill, Ontario, Canada, L4B 1L1

Actively Recruiting

26

The Hospital For Sick Children

Toronto, Ontario, Canada, M5G 1X8

Actively Recruiting

27

Skincare Studio Dermatology Centre

St. John's, Canada, A1E 1V4

Actively Recruiting

Loading map...

Research Team

I

Incyte Corporation Call Center (US)

CONTACT

I

Incyte Corporation Call Center (ex-US)

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here