Actively Recruiting
Pharmacokinetics Vancomycin CVVHDF with OXiris Membrane
Led by Mahidol University · Updated on 2025-01-24
8
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a general pharmacokinetic investigation of vancomycin in patients receiving continuous veno-venous hemodiafiltration (CRRT) with the oXiris membrane. This membrane offers the added benefit of absorbing inflammatory cytokines. In vitro studies show that vancomycin is reduced by around 20 percent in patients using the AN69ST membrane, which is part of the oXiris membrane's structure. However, there is currently a lack of in vivo studies demonstrating the impact of the oXiris membrane on vancomycin levels. Therefore, the hypothesis of this study is that vancomycin is also reduced by absorption in the oXiris membrane. This study measures the levels of vancomycin in these patients to determine the pharmacokinetic parameters.
CONDITIONS
Official Title
Pharmacokinetics Vancomycin CVVHDF with OXiris Membrane
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged more than 18 years.
- Admitted to the intensive care unit of Ramathibodi Hospital.
- Under continuous renal replacement therapy (CRRT) with CVVHDF using oXiris filter.
- Received vancomycin at least once after starting CRRT with CVVHDF using oXiris filter.
- Signed the informed consent document.
You will not qualify if you...
- History of vancomycin allergy.
- Expected to die within 24 hours after inclusion in study.
- Circuit clotting occurring more than 2 hours during the blood draw period.
- Treated with extracorporeal membrane oxygenation (ECMO).
- History of kidney transplantation.
- Pregnant or breastfeeding women.
- Decided to receive palliative care.
- On hemodialysis or peritoneal dialysis.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Facullty of Pharmacy Mahidol University
Bangkok, Payathi, Thailand, 10400
Actively Recruiting
Research Team
C
chidtawan Hirunsomboon, PharmD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here