Actively Recruiting
Pharmacological Activation of HMN for OSA Aim 2
Led by Brigham and Women's Hospital · Updated on 2022-09-21
16
Participants Needed
1
Research Sites
200 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon leads to increased collapsibility of UA compared to normal subjects. In this protocol the investigators will test the effect of LTM1201AZ, LTM1201AT, LTM1201AD, LTM1201AG administered before sleep on OSA phenotype traits and OSA severity during sleep.
CONDITIONS
Official Title
Pharmacological Activation of HMN for OSA Aim 2
Who Can Participate
Eligibility Criteria
You may qualify if you...
- AHI > 10 events/h during NREM supine sleep
You will not qualify if you...
- Any medical condition other than well controlled hypertension and mild diabetes
- Any medication known to influence breathing, sleep/arousal, or muscle physiology
- Claustrophobia
- Inability to sleep supine
- Allergy to any of the medications tested in the protocol
- History of kidney stones, hypercalcemia, primary hyperparathyroidism, sarcoidosis, hypervitaminosis D
- Individuals with underlying cardiac disease, such as arrhythmias
- Individuals taking psychiatric medications, such as an MAO-I, SSRI or SNRI, or any of the studied medications for medical care
- For women: Pregnancy
- Pulmonary hypertension
- Severe OSA with a mean SaO2 lower than 88%
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
5
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