Actively Recruiting
Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients
Led by Seoul National University Hospital · Updated on 2024-06-24
30
Participants Needed
1
Research Sites
85 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare the effect of use of reversal agents for neuromuscular blockade in critically ill patients on time for neurological assessment after endotracheal intubation The main questions it aims to answer are: * The use of reversal agents for neuromuscular blockade after endotracheal intubation may reduce the time for neurological assessment. * The types of reversal agents for neuromuscular blockade may affect the time for neurological assessment. Participants will receive different reversal agents or no medications based on the assigned groups. Thirty minutes after intubation using rocuronium, medication is administered, and the time of initial confirmation of eye opening and movement is recorded. Researchers will compare 3 groups (sugammadex, neostigmine and control(no medication) to see the difference of time for neurological assessment after endotracheal intubation.
CONDITIONS
Official Title
Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 19 years of age or older who were intubated after admission to the intensive care unit.
You will not qualify if you...
- Patients younger than 19 years of age
- Patients who are not neurologically evaluable or have concomitant neurologic dysfunction
- Patients with neuromuscular disorder
- Patients with a history of drug allergic reactions to sugammadex or neostigmine
- Patients taking or planning to take toremifene, fusidic acid, or hormonal contraceptives
AI-Screening
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Trial Site Locations
Total: 1 location
1
Seoul National University Hospital
Seoul, Jongno-gu, South Korea, 03080
Actively Recruiting
Research Team
L
Leerang Lim, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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