Actively Recruiting
PHArmacotherapy Assessed Using Neuroprobing With TransOsseal Magnetic Stimulation
Led by Insel Gruppe AG, University Hospital Bern · Updated on 2025-03-24
40
Participants Needed
1
Research Sites
258 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to investigate how prescribed anti-seizure medications (ASMs) affect cortical excitability in adults with epilepsy. The main questions it aims to answer are: 1. Does the magnitude of transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) measured with electroencephalography (EEG) change between OFF and ON medication states? 2. Do these changes in TEP amplitude persist over time? Researchers will compare each participant's measurements in the OFF state with those in the ON state to see if TEPs change following ASM (re)start. Participants will undergo one TMS-EEG session scheduled around their prescribed ASM (re)start and one 1-6 months later.
CONDITIONS
Official Title
PHArmacotherapy Assessed Using Neuroprobing With TransOsseal Magnetic Stimulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older with epilepsy prescribed anti-seizure medication for clinical reasons
- Written informed consent provided
You will not qualify if you...
- Electrical implants (e.g., neurostimulator or drug delivery system) or metallic implants in the head (excluding teeth)
- Increased intracranial pressure
- Uncontrolled psychiatric disorder
- Use of any drugs or alcohol (nicotine allowed)
- Pregnancy cannot be ruled out with sufficient certainty in female participants (pregnancy test required before TMS)
- Inability to provide informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Bern
Bern, Switzerland, 3010
Actively Recruiting
Research Team
C
Cecilia Friedrichs-Maeder, MD, MSc.
CONTACT
M
Maxime Baud, MD-Phd
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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