Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID06374277

Pharmacy-led Transitions of Care Intervention to Address System-Level Barriers and Improve Medication Adherence in Socioeconomically Disadvantaged Populations

Led by University of Tennessee · Updated on 2026-01-29

388

Participants Needed

2

Research Sites

4 weeks

Total Duration

On this page

Sponsors

U

University of Tennessee

Lead Sponsor

S

Sponsor GmbH

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are evaluating a pharmacy-led care transitions intervention designed to improve medication adherence among socioeconomically disadvantaged adults with multiple chronic conditions (MCC) after hospital discharge. This trial focuses on patients who are Medicaid recipients or uninsured, facing barriers such as financial challenges, transportation difficulties, and system-level obstacles. The study aims to address these issues through an innovative approach to reduce readmissions, healthcare costs, and mortality. The intervention includes providing essential chronic disease medications with zero copay, delivering medications first at the bedside and then to the patient's home, and offering care coordination by certified pharmacy technicians and health coaches. These coordinators assist with medication access, medication reconciliation, and ensure rapid and ongoing primary care follow-up after discharge. The intervention lasts for one year and is compared to usual care, which includes standard medication reconciliation and medication therapy management services where applicable. Participants will be followed for 12 months with assessments at 3, 6, 9, and 12 months to measure medication adherence, health care use including primary care follow-up, readmissions, hospitalizations, emergency visits, and costs. Qualitative interviews will explore patient experiences with the care transitions. Financial incentives are provided for completing follow-up surveys. The study's findings aim to inform healthcare systems and policymakers about effective ways to support medication adherence in vulnerable populations.

CONDITIONS

Brief Title

Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 21 years or older
  • Medicaid recipients or uninsured inpatients
  • Have two or more complex chronic conditions such as diabetes, hypertension, high cholesterol, coronary artery disease, congestive heart failure, chronic lung disease, chronic kidney disease, arrhythmia, stroke, depression, anxiety, or are prescribed anticoagulants
  • Using or prescribed two or more chronic medications for these conditions
  • Receiving chronic disease medications from the hospital pharmacy
Not Eligible

You will not qualify if you...

  • Patients who are dual eligible for Medicare and Medicaid
  • Hospital admission primarily for cancer, pregnancy, or an acute surgical procedure
  • Diagnoses of active psychosis, substance abuse, or suicidal ideation during hospital admission
  • Planned discharge location is not home
  • Participation in an existing pharmacy discharge program

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 1 year

Participants receive the pharmacy-led care transitions intervention or usual care to improve medication adherence after hospital discharge. The intervention includes medications with zero copay, bedside and home delivery of medications, and care coordination by pharmacy technicians to support medication access and rapid primary care follow-up.

Baseline visit and follow-up visits at 3, 6, 9, and 12 months

Qualitative Evaluation

Duration - 1 month and 12 months

Participants share their experiences with the care received during and after care transitions through interviews conducted to better understand the intervention's impact.

1 to 2 interview visits

Trial Site Locations

Total: 2 locations

1

University of Tennessee Medical Center

Knoxville, Tennessee, United States, 37920

Not Yet Recruiting

2

University of Tennessee Health Science Center/Regional One Health

Memphis, Tennessee, United States, 38103

Actively Recruiting

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Research Team

S

Satya Surbhi, PhD

E

Elizabeth A Tolley, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

HEALTH_SERVICES_RESEARCH

Number of Arms

2

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Frequently Asked Questions

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