Actively Recruiting
A Phase 1b Open-label Study to Evaluate Safety of Plamotamab in Participants With Rheumatoid Arthritis
Led by Xencor, Inc. · Updated on 2026-04-14
68
Participants Needed
3
Research Sites
136 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine the safety and tolerability of plamotamab in patients with rheumatoid arthritis. Participants will be given XmAb13676 subcutaneously (SC) by injection under the skin.
CONDITIONS
Official Title
A Phase 1b Open-label Study to Evaluate Safety of Plamotamab in Participants With Rheumatoid Arthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults with moderately to severely active rheumatoid arthritis
- Documented diagnosis of rheumatoid arthritis meeting 2010 classification criteria at least 3 months before screening
- Inadequate response, loss of response, or intolerance to available rheumatoid arthritis therapies
- Stable doses of rheumatoid arthritis medications before screening
- Use of highly effective contraception methods
You will not qualify if you...
- Major surgery within 12 weeks before screening or planned within 12 months after dosing
- Recurrent or active clinically significant infections
- Active or untreated latent tuberculosis
- Cancer or lymphoproliferative disease within the past 5 years
- Uncontrolled heart, lung, kidney, liver, endocrine, or gastrointestinal diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Xencor Investigative Site
Tbilisi, Georgia
Actively Recruiting
2
Xencor Investigative Site
Chisinau, Moldova
Actively Recruiting
3
Xencor Investigative Site
Auckland, New Zealand
Actively Recruiting
Research Team
N
Noriko Iikuni, MD, PhD
CONTACT
J
Jaime Mertz
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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