Actively Recruiting
A Phase 1b/2 Study of IM-101 in Adult Participants With Generalized Myasthenia Gravis and Ocular Myasthenia Gravis
Led by ImmunAbs Inc. · Updated on 2026-02-11
96
Participants Needed
25
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and potential efficacy of IM-101 in adult participants with AChR antibody-positive gMG. Subsequently, the safety and efficacy of the selected IM-101 dose-regimen will be tested in participants with AChR antibody-negative gMG and participants with AChR antibody-positive or AChR antibody-negative oMG.
CONDITIONS
Official Title
A Phase 1b/2 Study of IM-101 in Adult Participants With Generalized Myasthenia Gravis and Ocular Myasthenia Gravis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able and willing to provide signed informed consent
- Willing to consent to screening for genetic muscular diseases
- Male or female aged 6 18 years and < 75 years
- Diagnosed with myasthenia gravis
- On a stable dose of background therapy for myasthenia gravis
- Body weight 6 40 kg at screening
- Vaccinated against meningococcal infection, streptococcus pneumoniae, and haemophilus influenzae type B
You will not qualify if you...
- Previous exposure to IM-101
- Positive for anti-MuSK antibody
- History of malignant thymoma or cancer within the past 5 years
- History of Neisseria meningitidis infection
- Treated with any complement inhibitor and failed due to intolerability or lack of efficacy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 25 locations
1
Neurology of Central Florida Research Center, LLC
Altamonte Springs, Florida, United States, 32714
Actively Recruiting
2
SFM Clinical Research, LLC
Boca Raton, Florida, United States, 33487
Actively Recruiting
3
Aqualane Clinical Research
Naples, Florida, United States, 34105
Actively Recruiting
4
Medsol Clinical Research Center
Port Charlotte, Florida, United States, 33952
Not Yet Recruiting
5
University of South Florida
Tampa, Florida, United States, 33612
Not Yet Recruiting
6
University of Kansas Medical Center Research Institute, Inc.
Kansas City, Missouri, United States, 66103
Not Yet Recruiting
7
Nerve & Muscle Center of Texas
Houston, Texas, United States, 77030
Actively Recruiting
8
Houston Methodist Neurological Institute
Houston, Texas, United States, 77070
Not Yet Recruiting
9
Medical Center Hera - branch Montana
Montana, Bulgaria, 3400
Not Yet Recruiting
10
"MHAT Avis - Medica" OOD
Pleven, Bulgaria, 5800
Not Yet Recruiting
11
UMHAT 'Dr. Georgi Stranski', EAD
Pleven, Bulgaria, 5800
Not Yet Recruiting
12
UMHAT 'Tsaritsa Yoanna - ISUL', EAD
Sofia, Bulgaria, 1527
Not Yet Recruiting
13
Haelan Care 4 Medical Center EOOD
Varna, Bulgaria, 9009
Not Yet Recruiting
14
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
Brescia, Brescia, Italy, 25123
Not Yet Recruiting
15
Ospedale San Raffaele
Milan, Milano, Italy, 20132
Not Yet Recruiting
16
Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Milano, Italy, 20133
Not Yet Recruiting
17
Neurologia Slaska Centrum Medyczne
Katowice, Poland, 40-689
Not Yet Recruiting
18
Twoja Przychodnia NCM
Nowa Sól, Poland, 67-100
Not Yet Recruiting
19
Twoja Przychodnia PCM
Poznan, Poland, 60-324
Not Yet Recruiting
20
NZOZ Neuro-Kard Ilkowski i Partnerzy Spółka Partnerska Lekarzy
Poznan, Poland, 61-853
Not Yet Recruiting
21
Samodzielny Publiczny Szpital Kliniczny nr 1 im. Prof. Stanislawa Szyszko, SUM
Zabrze, Poland, 41-800
Not Yet Recruiting
22
General Hospital MSB Medical System Belgrade
Belgrade, Serbia, 11000
Not Yet Recruiting
23
Hospital Universitario Clinico San Carlos
Madrid, Madrid, Spain, 28040
Not Yet Recruiting
24
Hospital Universitario La Paz
Madrid, Madrid, Spain, 28046
Not Yet Recruiting
25
Clinica Universidad de Navarra
Pamplona, Navarre, Spain, 31008
Not Yet Recruiting
Research Team
I
ImmunAbs Clinical Team
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
7
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here