Actively Recruiting
Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)
Led by Vertex Pharmaceuticals Incorporated · Updated on 2026-05-13
24
Participants Needed
42
Research Sites
110 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to evaluate the effect of VX-407 on height-adjusted total kidney volume (htTKV), safety, tolerability, and pharmacokinetics (PK) of VX-407.
CONDITIONS
Official Title
Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Autosomal Dominant Polycystic Kidney Disease (ADPKD) as defined in the protocol
- Willing and able to comply with scheduled visits and study procedures
- Mayo imaging classification (MIC) status of 1B (with htTKV 250 mL/m), 1C, 1D, or 1E confirmed by abdominal MRI during screening
- Estimated glomerular filtration rate (eGFR) 25 mL/min/1.73 m
You will not qualify if you...
- History of kidney disease other than ADPKD that may affect the course of ADPKD
- History of solid organ or bone marrow transplant or kidney removal (nephrectomy)
- Currently receiving or planning to start renal replacement therapy within 12 months of screening
- Other protocol defined exclusion criteria apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 42 locations
1
Alabama Kidney Research
Alabaster, Alabama, United States, 35007
Actively Recruiting
2
UAB Nephrology Research at CH19
Birmingham, Alabama, United States, 35294
Actively Recruiting
3
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States, 90027
Actively Recruiting
4
UCSF Clinical Research Center at Parnassus
San Francisco, California, United States, 94143
Actively Recruiting
5
Nephrology & Hypertension Associates, PC
Middlebury, Connecticut, United States, 06762
Actively Recruiting
6
Yale University - Yale Nephrology Clinical Research Clinic
New Haven, Connecticut, United States, 06510
Actively Recruiting
7
Mayo Clinic - Jacksonville
Jacksonville, Florida, United States, 32224
Actively Recruiting
8
Emory School of Medicine - Renal Division
Atlanta, Georgia, United States, 30322
Actively Recruiting
9
Renal Associates
Columbus, Georgia, United States, 31904
Actively Recruiting
10
UChicago Medicine - Duchossois Center for Advanced Medicine - Nephrology
Chicago, Illinois, United States, 60637
Actively Recruiting
11
University of Iowa Health Care Medical Center- Nephrology
Iowa City, Iowa, United States, 52242
Actively Recruiting
12
Clinical & Translational Science Unit (CTSU) - Nephrology
Kansas City, Kansas, United States, 66160
Actively Recruiting
13
University of Maryland Medical Center - General Clinical Research Center
Baltimore, Maryland, United States, 21201
Actively Recruiting
14
Tufts Medical Center
Boston, Massachusetts, United States, 02111
Actively Recruiting
15
Beth Israel Deaconess Medical Center - Nephrology
Boston, Massachusetts, United States, 02215
Actively Recruiting
16
University of Minnesota -Clinics and Surgery Center (CSC) - Endocrine Clinic
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
17
Mayo Clinic - Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
18
DaVita Kidney Care - Las Vegas
Las Vegas, Nevada, United States, 89107
Actively Recruiting
19
The Rogosin Kidney Center
New York, New York, United States, 10021
Actively Recruiting
20
General Nephrology Clinic - New York City
New York, New York, United States, 10032
Actively Recruiting
21
Cleveland Clinic - Main Campus
Cleveland, Ohio, United States, 44195
Actively Recruiting
22
Geisinger Clinic
Danville, Pennsylvania, United States, 17822
Actively Recruiting
23
Perelman Center for Advanced Medicine - Nephrology
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
24
Nephrology Clinical Trials Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
25
UVM Medical Center - 1 South Prospect Street
Burlington, Vermont, United States, 05401
Actively Recruiting
26
Swedish Center for Comprehensive Care
Seattle, Washington, United States, 98104
Actively Recruiting
27
Universite Catholique de Louvain - Nephrology
Brussels, Belgium
Actively Recruiting
28
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg - Nephrology
Leuven, Belgium
Actively Recruiting
29
McGill University Health Centre
Montreal, Canada
Actively Recruiting
30
Centre Hospitalier Regional Universitaire (CHRU) Brest
Brest, France
Actively Recruiting
31
Hopital Necker Enfants Malades - Neurology
Paris, France
Actively Recruiting
32
Charité - Klinik für Nephrologie und Intensivmedizin der
Berlin, Germany
Actively Recruiting
33
University Hospital Cologne (Koeln) - Nephrologie, Rheumatologie, Diabetologie und Allgemeine Innere Medizin
Cologne, Germany
Actively Recruiting
34
UMCG - Nephrology
Groningen, Netherlands
Actively Recruiting
35
Fundacio Puigvert
Barcelona, Spain
Actively Recruiting
36
Hospital Fundacion Jimenez Diaz
Madrid, Spain
Actively Recruiting
37
Queen Elizabeth Hospital Birmingham
Birmingham, United Kingdom
Actively Recruiting
38
King's College Hospital - Pulmonology
London, United Kingdom
Actively Recruiting
39
Royal Free Hospital - Nephrology
London, United Kingdom
Actively Recruiting
40
St George's Hospital London - Nephrology
London, United Kingdom
Actively Recruiting
41
Newcastle upon Tyne Hospitals NHS Foundation Trust - Freeman Hospital - Nephrology
Newcastle upon Tyne, United Kingdom
Actively Recruiting
42
Northern General Hospital
Sheffield, United Kingdom
Actively Recruiting
Research Team
M
Medical Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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