Actively Recruiting
A Phase 2b, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Camoteskimab in Adults With Moderate-to-Severe Atopic Dermatitis
Led by Apollo Therapeutics Ltd · Updated on 2026-06-02
280
Participants Needed
85
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating camoteskimab, a drug being studied in adults with moderate-to-severe atopic dermatitis. This phase 2b study is multicenter, randomized, double-blind, and placebo-controlled, aiming to assess the drug's effects compared to placebo. Participants include those who have not been treated before and those who have had an inadequate response to previous biologic therapies. The study has two parts: Part 1 is a 24-week period where participants are randomly assigned to one of four groups receiving one of three doses of camoteskimab or a placebo, all given by subcutaneous injection. In Part 2, an extension period, all participants will receive camoteskimab. This design allows researchers to compare the drug doses with placebo initially and then provide treatment to all participants. Participants will be involved for at least 24 weeks in the placebo-controlled phase and beyond during the extension. They will undergo assessments including the Eczema Area and Severity Index (EASI), Investigator Global Assessment (IGA), and peak itch ratings. Researchers will measure changes in eczema severity, itch intensity, and skin condition over time. Safety and adherence will be monitored throughout the study period to evaluate the drug's effects and tolerability.
CONDITIONS
Brief Title
A Phase 2b Study of the Effects of Camoteskimab in Adults With Moderate-to-Severe Atopic Dermatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 65 years at the time of informed consent
- Chronic atopic dermatitis for at least 1 year confirmed by clinical diagnosis
- Moderate-to-severe atopic dermatitis defined by: IGA score of 3 or higher at screening and baseline
- Atopic dermatitis affecting 10% or more of body surface area at screening and baseline
- EASI score of 16 or higher at screening and baseline
- Peak pruritus numerical rating scale (PP-NRS) score of 4 or higher at baseline with at least 4 daily scores out of 7 days
- Candidates for systemic therapy due to inadequate response to topical treatments or medical inadvisability of topical treatments
- Use of contraception consistent with local regulations for clinical studies
- Signed informed consent provided
You will not qualify if you...
- Severe illness or psychiatric conditions such as severe depression or suicidal attempt in past 10 years judged unsuitable for the study
- Active infection requiring systemic antibiotics, antivirals, antiparasitics, antiprotozoals, or antifungals within 2 weeks before baseline
- Other active skin diseases or infections that affect atopic dermatitis evaluation
- Significant flares of atopic dermatitis within 4 weeks before screening
- Severe comorbidities requiring systemic steroids or frequent monitoring
- Clinically significant ECG abnormalities affecting QTc interval assessment
- Severe uncontrolled seasonal or allergic rhinitis, asthma, or other atopic diseases
- Use of medicated moisturizers by prescription within 2 weeks prior to baseline
- Active HIV, hepatitis B, hepatitis C (unless cured), or tuberculosis
- Live or attenuated live vaccine within 6 weeks before screening
- Major surgery within 8 weeks before baseline or planned during the study
- Known immune deficiency or immunocompromised state
- Malignancy diagnosed within 5 years except certain skin or cervical cancers
- Previous exposure to anti-IL-18 therapy
- Known allergy to any component of the investigational product
- Recent use of specific medications affecting atopic dermatitis including certain biologics, JAK inhibitors, topical and systemic treatments within specified time frames
- Pregnancy, breastfeeding, or trying to conceive
- Unlikely to adhere to treatment or protocol as judged by investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey: What to Expect
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 24 weeks
Participants receive camoteskimab or placebo administered subcutaneously during a 24-week placebo-controlled period.
Regular visits during the 24-week treatment period
Duration - Duration of extension period following 24 weeks
Participants receive camoteskimab during the extension period following the placebo-controlled period.
Visits continue during the extension period
Trial Site Locations
Total: 85 locations
1
AllerVie Clinical Research
Birmingham, Alabama, United States, 35209
Not Yet Recruiting
2
Cahaba Dermatology and Skin Health Center
Birmingham, Alabama, United States, 35244
Not Yet Recruiting
3
Saguaro Dermatology Associates
Phoenix, Arizona, United States, 85018
Not Yet Recruiting
4
Dermatology Trial Associates, Inc
Bryant, Arkansas, United States, 72022
Not Yet Recruiting
5
Marvel Research, LLC
Huntington Beach, California, United States, 92648
Not Yet Recruiting
6
Metropolis Dermatology
Los Angeles, California, United States, 90025
Not Yet Recruiting
7
Dermatology Research Associates
Los Angeles, California, United States, 90048
Not Yet Recruiting
8
University of California Los Angeles
Los Angeles, California, United States, 90095
Not Yet Recruiting
9
Northridge Clinical Trials
Northridge, California, United States, 91325
Actively Recruiting
10
Integrative Skin Science and Research
Sacramento, California, United States, 95815
Actively Recruiting
11
Valiance Clinical Research - Tarzana
Tarzana, California, United States, 91356
Not Yet Recruiting
12
Paradigm Clinical Research Centers, LLC: Wheat Ridge
Wheat Ridge, Colorado, United States, 80033
Not Yet Recruiting
13
ABMED Clinical Research Corp.
Cape Coral, Florida, United States, 33904
Not Yet Recruiting
14
International Dermatology Research, INC
Hollywood, Florida, United States, 33021
Not Yet Recruiting
15
Quality Care Clinical Research
Miami, Florida, United States, 33101
Not Yet Recruiting
16
FXM Clinical Research Miami, LLC
Miami, Florida, United States, 33155
Not Yet Recruiting
17
Eminent Clinical Research and Associates
North Lauderdale, Florida, United States, 33068
Not Yet Recruiting
18
Ziaderm Research LLC
North Miami Beach, Florida, United States, 33162
Not Yet Recruiting
19
NMC Research LLC
Tampa, Florida, United States, 33614
Not Yet Recruiting
20
Elligo - Georgia Skin & Cancer Clinic (Sidney P. Smith, MD, PC)
Savannah, Georgia, United States, 31406
Not Yet Recruiting
21
Ada West Research, LLC
Meridian, Idaho, United States, 83646
Actively Recruiting
22
Endeavor Health
Skokie, Illinois, United States, 60077
Not Yet Recruiting
23
DS Research of Southern Indiana,LLC
Clarksville, Indiana, United States, 47129
Actively Recruiting
24
Dawes Fretzin Clinical Research Group, LLC
Columbus, Indiana, United States, 47201
Not Yet Recruiting
25
Chesapeake Clinical Research, Inc
Pasadena, Maryland, United States, 21122
Not Yet Recruiting
26
Skin Cancer and Dermatology Institute
Reno, Nevada, United States, 89509
Actively Recruiting
27
Trail Horizon
Clifton, New Jersey, United States, 07013
Not Yet Recruiting
28
Sadick Research Group, LLC
New York, New York, United States, 10021
Actively Recruiting
29
Red River Research Partners, LLC
Fargo, North Dakota, United States, 58103
Not Yet Recruiting
30
ClinOhio Research Services
Columbus, Ohio, United States, 43213
Actively Recruiting
31
Best Skin Research, LLC
Camp Hill, Pennsylvania, United States, 17011
Actively Recruiting
32
UPMC Department of Dermatology
Pittsburgh, Pennsylvania, United States, 15213
Not Yet Recruiting
33
Progressive Clinical Research, PA
San Antonio, Texas, United States, 78213
Actively Recruiting
34
Medical Center Medconsult Burgas EOOD
Burgas, Bulgaria
Not Yet Recruiting
35
Medical Center Kazanlak EOOD
Kazanlak, Bulgaria
Not Yet Recruiting
36
Medical Center Medconsult Pleven-Lovech Branch
Lovech, Bulgaria
Not Yet Recruiting
37
Medical Center Medconsult Pleven OOD
Pleven, Bulgaria
Not Yet Recruiting
38
Medical Centre Pratia Clinic EOOD
Varna, Bulgaria
Not Yet Recruiting
39
Beacon Dermatology
Calgary, Alberta, Canada
Not Yet Recruiting
40
Laser Rejuvenation Clinics Edmonton D.T. Inc.
Calgary, Alberta, Canada
Not Yet Recruiting
41
Laser Rejuvenation Clinics Edmonton D.T. Inc.
Edmonton, Alberta, Canada
Not Yet Recruiting
42
Rejuvenation Dermatology Clinic Edmonton South
Edmonton, Alberta, Canada
Not Yet Recruiting
43
DermEdge Research
Mississauga, Ontario, Canada
Not Yet Recruiting
44
FACET Dermatology
Toronto, Ontario, Canada
Not Yet Recruiting
45
North York Research Inc.
Toronto, Ontario, Canada
Not Yet Recruiting
46
Centre de Recherche Saint-Louis (Sherbrooke)
Sherbrooke, Quebec, Canada
Actively Recruiting
47
Saskatoon Dermatology Centre
Saskatoon, Saskatchewan, Canada
Actively Recruiting
48
CCR Ostrava s.r.o.
Ostrava, Czechia
Not Yet Recruiting
49
Pratia Pardubice a.s.
Pardubice, Czechia
Not Yet Recruiting
50
Clintrial s.r.o.
Prague, Czechia
Not Yet Recruiting
51
Fakultni Nemocnice Kralovske Vinohrady
Prague, Czechia
Not Yet Recruiting
52
Praglandia s.r.o.
Prague, Czechia
Not Yet Recruiting
53
Pratia Prague
Prague, Czechia
Not Yet Recruiting
54
Fachklinik Bad Bentheim
Bad Bentheim, Germany
Not Yet Recruiting
55
University Hospital Dresden
Dresden, Germany
Not Yet Recruiting
56
Universitatsklinikum Frankfurt Klinik fur Dermatologie, Venerologie und Allergologie
Frankfurt, Germany
Not Yet Recruiting
57
Dermatologikum Hamburg GmbH
Hamburg, Germany
Not Yet Recruiting
58
University of Luebeck
Lübeck, Germany
Not Yet Recruiting
59
University Hospital of Muenster
Münster, Germany
Not Yet Recruiting
60
Hautarztpraxis Dr. Hoffmann
Witten, Germany
Not Yet Recruiting
61
Trial Pharma Kft.
Békéscsaba, Hungary
Not Yet Recruiting
62
Dept. Dermatology, Venereology and Dermatooncology, Semmelweis University
Budapest, Hungary
Not Yet Recruiting
63
Debreceni Egyetem - Orvos es Egeszsegtudomanyi Centrum (DEOEC) (University of Debrecen Medical and Health Science Center)
Debrecen, Hungary
Not Yet Recruiting
64
Pecsi Tudomanyegyetem
Pécs, Hungary
Not Yet Recruiting
65
Komplex Labor Kft
Szeged, Hungary
Not Yet Recruiting
66
University of Szeged
Szeged, Hungary
Not Yet Recruiting
67
NZOZ Centrum Medyczne KERmed
Bydgoszcz, Poland
Not Yet Recruiting
68
OptiTrial
Chojnice, Poland
Not Yet Recruiting
69
Dermedea Clinic
Gdansk, Poland
Not Yet Recruiting
70
CM Pratia Katowice
Katowice, Poland
Not Yet Recruiting
71
Provita Sp. z o. o.
Katowice, Poland
Not Yet Recruiting
72
Klinika Zdybski - Dermedic (Kielce)
Kielce, Poland
Not Yet Recruiting
73
Clinical Best Solution Sp. z o.o.
Lublin, Poland
Not Yet Recruiting
74
NZOZ Hipokrates
Piotrkow Trybunalski, Poland
Not Yet Recruiting
75
Twoja Przychodnia Poznanskie Centrum Medyczne Sp.
Poznan, Poland
Not Yet Recruiting
76
Laser Clinic S.C. Andrzej Krolicki, Tomasz Kochanowski
Szczecin, Poland
Not Yet Recruiting
77
Twoja Przychodnia Szczecinskie Centrum Medyczne Sp. z o.o.
Szczecin, Poland
Not Yet Recruiting
78
Klinika Ambroziak Dermatologia
Warsaw, Poland
Not Yet Recruiting
79
Medicus Clinic
Wroclaw, Poland
Not Yet Recruiting
80
Softskin Medical Center Dr Elzbieta Wojtowicz-Prus
Wroclaw, Poland
Not Yet Recruiting
81
Hospital General Universitario Dr. Balmis
Alicante, Spain
Not Yet Recruiting
82
Hospital Universitari Germans Trias i Pujol
Badalona, Spain
Not Yet Recruiting
83
Hospital Universitario La Paz
La Paz, Spain
Not Yet Recruiting
84
Complejo Hospitalario Universitario de Santiago de Compostela
Santiago de Compostela, Spain
Not Yet Recruiting
85
Hospital Universitario Miguel Servet
Zaragoza, Spain
Not Yet Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here