Actively Recruiting

Phase 3
Age: 18Years +
All Genders
NCT06162286

A Phase 3b Randomized, Double-blind, Multi-center Study to Compare the Safety and Efficacy of Omadacycline to Moxifloxacin for Treating Adult Subjects With CABP

Led by Zai Lab (Hong Kong), Ltd. · Updated on 2024-06-14

100

Participants Needed

40

Research Sites

106 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The primary objective of the study is to show that in Chinese adults with CABP, a course of IV/PO treatment with omadacycline has similar clinical efficacy as the with the comparator antibiotic, IV/PO moxifloxacin. The study is designed as a bridging study, to confirm the results of the pivotal global CABP trial in an ethnically different population of Chinese.

CONDITIONS

Official Title

A Phase 3b Randomized, Double-blind, Multi-center Study to Compare the Safety and Efficacy of Omadacycline to Moxifloxacin for Treating Adult Subjects With CABP

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Written and signed informed consent before any study assessments
  • Male or female aged 18 years or older
  • Has at least 3 of these symptoms: cough, producing purulent sputum, shortness of breath, chest pain
  • Has at least 2 abnormal vital signs: fever (>38.0°C) or low temperature (<36.0°C), low systolic blood pressure (<90 mmHg), heart rate >90 bpm, respiratory rate >20 breaths/min
Not Eligible

You will not qualify if you...

  • Received more than 24 hours of antibacterial treatment within 72 hours before randomization, except short-acting antimicrobials for ≤24 hours or >48 hours of prior therapy with clear evidence of treatment failure
  • Known or suspected CABP caused by pathogens possibly resistant to the study drugs, including Klebsiella pneumoniae, Pseudomonas aeruginosa, Pneumocystis jiroveci, obligate anaerobes, mycobacteria, or fungal pathogens
  • Suspected or confirmed empyema or lung abscess

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 40 locations

1

Beijing Tsinghua Chang Gung Hospital/Infectious Diseases Department

Beijing, China

Actively Recruiting

2

Peking University Shougang Hospital/Respiratory and Critical Care Medicine Department

Beijing, China

Actively Recruiting

3

The First Affiliated Hospital of Bengbu Medical College/Intensive care unit

Bengbu, China

Actively Recruiting

4

The Central Hospital of Changsha/Department of Respiratory and Critical Care Medicine

Changsha, China

Actively Recruiting

5

The Third Hospital of Changsha/Respiratory and Critical Care Medicine Department

Changsha, China

Actively Recruiting

6

Xiangya Hospital Central South University/Department of Respiratory and Critical Care Medicine

Changsha, China

Actively Recruiting

7

West China Hospital of Sichuan University/Infectious Disease Center

Chengdu, China

Actively Recruiting

8

The First People's Hospital of Foshan/Department of Respiratory and Critical Care Medicine

Foshan, China

Actively Recruiting

9

Fuyang People's Hospital/Department of Respiratory and Critical Care Medicine

Fuyang, China

Actively Recruiting

10

The First Affiliated Hospital of Gannan Medical University/Pneumology Department

Gannan, China

Actively Recruiting

11

Guangdong Second Central Hospital/Department of Respiratory and Critical Care Medicine

Guangzhou, China

Actively Recruiting

12

Guangzhou First People's Hospital/Respiratory and Critical Care Medicine Department

Guangzhou, China

Actively Recruiting

13

The First Affiliated Hospital of Guangzhou Medical University/Respiratory Medicine

Guangzhou, China

Actively Recruiting

14

The Hospital of Zhejiang/Respiratory Medicine

Hangzhou, China

Actively Recruiting

15

Jiangyin People's Hospital/Department of Respiratory and Critical Care Medicine

Jiangyin, China

Actively Recruiting

16

The First Hospital of Jiaxing/Pneumology Department

Jiaxing, China

Actively Recruiting

17

Kunming First People's Hospital/Respiratory Medicine

Kunming, China

Actively Recruiting

18

The Central Hospital of Luoyang/Department of Respiratory and Critical Care Medicine

Luoyang, China

Actively Recruiting

19

The Central Hospital of Mianyang/Department of Respiratory and Critical Care Medicine

Mianyang, China

Actively Recruiting

20

Jiangxi Province People's Hospital/Pneumology Department

Nanchang, China

Actively Recruiting

21

The First Affiliated Hospital of Nanchang University

Nanchang, China

Actively Recruiting

22

The First People's Hospital of Nanning/Department of Respiratory and Critical Care Medicine

Nanning, China

Actively Recruiting

23

The People's Hospital of Guangxi Zhuang Autonomous Region/Department of Respiratory and Critical Care Medicine

Nanning, China

Actively Recruiting

24

Quanzhou First Hospital/Infectious Disease Department

Quanzhou, China

Actively Recruiting

25

Huashan Hospital

Shanghai, China

Actively Recruiting

26

Shanghai Fifth People's Hospital,Fudan University/Department of Respiratory and Critical Care Medicine

Shanghai, China

Withdrawn

27

Shanghai Pulmonary Hospital/Respiratory and Critical Care Medicine Department

Shanghai, China

Actively Recruiting

28

The Central Hospital of Shenyang/Department of Respiratory and Critical Care Medicine

Shenyang, China

Actively Recruiting

29

Shenzhen People's Hospital/Department of Respiratory and Critical Care Medicine

Shenzhen, China

Actively Recruiting

30

Shijiazhuang People's Hospital/Respiratory Medicine

Shijia Zhuang, China

Actively Recruiting

31

Suzhou Municipal Hospital/Department of Respiratory and Critical Care Medicine

Suzhou, China

Actively Recruiting

32

The 2nd Affiliated Hospital of Wenzhou Medical University/Department of Respiratory and Critical Care Medicine

Wenzhou, China

Actively Recruiting

33

Wenzhou Central Hospital/Department of Respiratory and Critical Care Medicine

Wenzhou, China

Actively Recruiting

34

The Central Hospital of Wuhan/Respiratory and Critical Care Medicine Department

Wuhan, China

Actively Recruiting

35

Zhongshan Hospital Xiamen University/Pneumology Department

Xiamen, China

Actively Recruiting

36

The First Affiliated Hospital of Xinjiang Medical University/Pneumology Department

Xinjiang, China

Actively Recruiting

37

The Central Hospital of Xinxiang/Department of Respiratory and Critical Care Medicine

Xinxiang, China

Actively Recruiting

38

People's Hospital of Ningxia Hui Autonomous Region/Pneumology Department

Yinchuan, China

Withdrawn

39

Zhejiang Provincial People's Hospital/Respiratory Medicine

Zhejiang, China

Actively Recruiting

40

Zibo Municipal Hospital/Department of Respiratory and Critical Care Medicine

Zibo, China

Actively Recruiting

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Research Team

H

Harriet Li

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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