Actively Recruiting
Phase II Clinical Study of Probiotic LR607 in Patients With Non-Small Cell Lung Cancer
Led by Zhujiang Hospital · Updated on 2026-04-16
46
Participants Needed
1
Research Sites
106 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to understand whether Lactobacillus rhamnosus LR607 can enhance neoadjuvant chemoimmunotherapy for adult patients with non-small cell lung cancer. It will also evaluate the safety of LR607. The main questions it aims to answer include: Can LR607 improve the major pathological response of neoadjuvant chemoimmunotherapy? What is the relationship between LR607 combined with neoadjuvant chemoimmunotherapy and treatment-related adverse reactions? What changes occur in the gut microbiota composition at the species level and gut metabolites of subjects after LR607 treatment? Participants will: Take LR607 daily for 3 months Visit the hospital for check-ups and examinations every month Record their pathological response, tumor recurrence, and treatment-related adverse reactions
CONDITIONS
Official Title
Phase II Clinical Study of Probiotic LR607 in Patients With Non-Small Cell Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed newly diagnosed patients
- ECOG performance status 0-1
- Age 18 years or older
- Measurable lesions according to RECIST v1.1
- Organ function suitable for chemotherapy and immunotherapy
You will not qualify if you...
- Active autoimmune diseases
- Recent use of immunosuppressants
- Interstitial lung disease
- Other malignancies
- History of immunotherapy
- Active infection
- Pregnancy or drug allergies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhu Jiang Hospital of Southern Medical University
Guangzhou, China
Actively Recruiting
Research Team
X
Xin Li
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here