Actively Recruiting
Phase II Randomized Study of Hypofractionated Versus Conventional Radiotherapy
Led by University of Texas Southwestern Medical Center · Updated on 2025-11-26
67
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To compare the acute tolerance of highly conformal hypofractionated versus conventional radiotherapy.
CONDITIONS
Official Title
Phase II Randomized Study of Hypofractionated Versus Conventional Radiotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathologically-proven squamous cell carcinoma or its variants involving the glottic larynx
- Clinical stage 0 to II larynx cancer with no regional disease
- Age 18 years or older
- ECOG Performance Status between 0 and 2
- Women of child-bearing potential and men agree to use effective contraception during and 90 days after treatment
- Ability to understand and sign informed consent
You will not qualify if you...
- AJCC stage III or IV larynx cancer
- Arytenoid cartilage involvement beyond the vocal process
- Prior chemotherapy for the targeted larynx lesion
- Synchronous primary cancers in the head and neck
- Previous radiotherapy overlapping the study area
- Smoking more than one pack of cigarettes per day
- Receiving other investigational agents
- Uncontrolled illnesses including active infections, symptomatic heart failure, unstable angina, arrhythmias, or psychiatric/social issues affecting compliance
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
D
David J Sher, MD,MPH
CONTACT
S
Sarah Neufeld
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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