Actively Recruiting
A Phase II Study of CRT Combined With QL1706 in ESCC Patients
Led by Tianjin Medical University Cancer Institute and Hospital · Updated on 2024-05-21
39
Participants Needed
1
Research Sites
161 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single arm, multi-center Phase II Study. This clinical study is an investigator-initiated clinical trial（IIT). The objective of this study is to evaluate the efficacy and safety of Chemoradiationtherapy combined with QL1706 (anti-CTLA-4 and PD-1 antibody) in patients with unresectable locally advanced esophageal squamous cell carcinoma.
CONDITIONS
Official Title
A Phase II Study of CRT Combined With QL1706 in ESCC Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must voluntarily agree and sign informed consent.
- Age between 18 and 75 years, male or female.
- Histologically confirmed advanced unresectable esophageal squamous cell carcinoma of clinical stage II-IVa according to AJCC 8th Edition (cT1N2-3M0, cT2-4bN0-3M0).
- At least one measurable or unmeasurable target lesion per RECIST 1.1 criteria.
You will not qualify if you...
- History of esophageal cancer surgery.
- Previous fistula caused by tumor infiltration.
- High risk of gastrointestinal bleeding, esophageal fistula, or esophageal perforation.
- Poor nutritional status with weight loss of 10% or more in the past 2 months without improvement after nursing intervention.
- Major surgery or serious trauma within 4 weeks before starting the study drug.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tianjin cancer hospital
Tianjin, Tianjin Municipality, China, 300060
Actively Recruiting
Research Team
Q
Qingsong Pang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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