Actively Recruiting
Phase II Study of Daily Adaptive Radiotherapy for Submandibular Gland-sparing in Head and Neck Cancer
Led by University Health Network, Toronto · Updated on 2026-03-04
50
Participants Needed
1
Research Sites
206 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a randomized, single centre, single blinded prospective study comparing the standard of care imaging guided radiation therapy and daily adaptive radiotherapy (ART) for submandibular gland-sparing in head and neck cancer
CONDITIONS
Official Title
Phase II Study of Daily Adaptive Radiotherapy for Submandibular Gland-sparing in Head and Neck Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Histologically confirmed squamous cell carcinoma of the head and neck
- Both sides of the neck planned for treatment
- At least one level 1b lymph node area not treated electively and no target structures within 1 cm of the spared submandibular gland except elective level II/III
- Eastern Cooperative Oncology Group performance status of 0 to 2
- Planned for curative chemotherapy and/or radiotherapy
- Able to understand study information and provide written informed consent
- Able to lie on the back comfortably and wear immobilization for up to 1 hour
You will not qualify if you...
- Evidence of systemic disease making the patient unsuitable for the study as judged by the investigator
- Pregnancy
- Existing salivary gland dysfunction before treatment that may affect benefit from adaptive radiotherapy as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
Research Team
A
Andrew McPartlin, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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