Actively Recruiting
A Phase II Study Evaluating JAB-21822 Monotherapy in Adult Patients With Pancreatic Cancer and Other Solid Tumors Harboring the KRAS p.G12C Mutation.
Led by Allist Pharmaceuticals, Inc. · Updated on 2026-03-13
88
Participants Needed
31
Research Sites
218 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with other advanced solid tumors (excluding NSCLC and CRC) who have progressed after prior systemic therapy or are intolerant and lack satisfactory alternative treatment options, aiming to evaluate the efficacy and safety of Glecirasib in these patients.
CONDITIONS
Official Title
A Phase II Study Evaluating JAB-21822 Monotherapy in Adult Patients With Pancreatic Cancer and Other Solid Tumors Harboring the KRAS p.G12C Mutation.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed KRAS p.G12C mutation using validated diagnostic tests
- Locally advanced, unresectable, or metastatic solid tumors excluding NSCLC and CRC
- For pancreatic cancer, prior progression or intolerance to gemcitabine-based chemotherapy or FOLFIRINOX/mFOLFIRINOX/NALIRIFOX
- For other solid tumors, progression or intolerance to prior systemic therapies with no satisfactory alternatives
You will not qualify if you...
- Previous treatment with any KRAS G12C inhibitor
- History of interstitial lung disease, non-infectious pneumonia, or uncontrolled lung disease with symptoms
- Uncontrolled pleural effusion, pericardial effusion, or ascites
- QTcF interval of 470 ms or longer based on three electrocardiograms
- Use of drugs with known risk of torsades de points within 14 days before first dose
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 31 locations
1
Anhui Provincial Cancer Hospital
Hefei, Anhui, China
Actively Recruiting
2
Beijing Cancer Hospital
Beijing, Beijing Municipality, China, 100142
Actively Recruiting
3
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100730
Actively Recruiting
4
Beijing Tsinghua Changgung Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
5
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China
Actively Recruiting
6
Fujian Cancer Hospital
Fuzhou, Fujian, China
Actively Recruiting
7
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
Actively Recruiting
8
Sun Yat-Sen University Cancer Center
Guangzhou, Guangdong, China
Actively Recruiting
9
The First Affiliated Hospital of Sun, Yat-sen University
Guangzhou, Guangdong, China
Actively Recruiting
10
Guangxi Medical University Cancer Hospital
Nanning, Guangxi, China
Actively Recruiting
11
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China
Actively Recruiting
12
Henan Cancer Hospital
Zhengzhou, Henan, China
Actively Recruiting
13
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Actively Recruiting
14
Hubei Cancer Hospital
Wuhan, Hubei, China
Actively Recruiting
15
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
Actively Recruiting
16
Hunan Cancer Hospital
Changsha, Hunan, China
Actively Recruiting
17
Hunan Provincial People's Hospital
Changsha, Hunan, China
Actively Recruiting
18
Jiangsu Cancer Hospital
Nanjing, Jiangsu, China
Actively Recruiting
19
Jiangsu Province Hospital
Nanjing, Jiangsu, China
Actively Recruiting
20
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
Actively Recruiting
21
The First Hospital of China Medical University
Shenyang, Liaoning, China
Actively Recruiting
22
Shandong Cancer Hospital
Jinan, Shandong, China
Actively Recruiting
23
The Affiliated Hospital of Qingdao University
Qingdao, Shandong, China
Not Yet Recruiting
24
Huashan Hospital, Fudan University
Shanghai, Shanghai Municipality, China
Actively Recruiting
25
Shanghai Changhai Hospital
Shanghai, Shanghai Municipality, China
Actively Recruiting
26
The First Affiliated Hospital of Xi'an Jiaotong University
Xi’an, Shanxi, China
Actively Recruiting
27
West China Hospital of Sichuan University
Chengdu, Sichuan, China
Actively Recruiting
28
Tianjin Medical University Cancer Institute＆Hospital
Tianjin, Tianjin Municipality, China
Actively Recruiting
29
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Not Yet Recruiting
30
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China
Actively Recruiting
31
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
S
Shanghai Allist Pharmaceuticals Co., Ltd
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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