Actively Recruiting
Phase II Study of Intensity Modulated Radiotherapy in Dose Painting for Sinus Carcinomas After Endoscopic Surgery
Led by Centre Francois Baclesse · Updated on 2025-07-28
52
Participants Needed
3
Research Sites
259 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The patient is randomized to one of the following groups: * Experimental group: Radiotherapy in painting dose on histoscannographic mapping * Control group: standard pan-sinus radiotherapy
CONDITIONS
Official Title
Phase II Study of Intensity Modulated Radiotherapy in Dose Painting for Sinus Carcinomas After Endoscopic Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients older than 18 years
- Histologically confirmed malignant tumor of the sinuses, excluding melanoma, lymphoma, and mesenchymal tumors (sarcoma)
- Endoscopic sinonasal surgery with histosurgical mapping done within 2 months before radiotherapy
- Indication for radiotherapy (photon or proton therapy) without prior neoadjuvant chemotherapy (concomitant chemotherapy allowed)
- Signed informed consent before any study-specific procedure
- Affiliated to a social security system
You will not qualify if you...
- Tumor not operated in place
- Presence of distant metastases
- Treatment with neoadjuvant chemotherapy
- Pregnant or breastfeeding women, or absence of contraception during reproductive activity
- History of other malignant disease within the last 3 years, except basal cell skin cancer, carcinoma in situ, or superficial bladder tumor; other solid tumors or lymphoma must be treated and without recurrence for at least 3 years
- Participation in another therapeutic clinical trial
- Patients deprived of liberty, under guardianship, curatorship, legal protection, or unable to give consent
- Inability to comply with trial monitoring due to geographic, social, or psychological reasons
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Centre Francois Baclesse
Caen, France
Actively Recruiting
2
CHU CAEN
Caen, France
Not Yet Recruiting
3
Centre Oscar Lambret
Lille, France
Not Yet Recruiting
Research Team
V
Vincent PATRON, MD
CONTACT
J
Juliette THARIAT, Prof
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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