Actively Recruiting
Phase II Study of Resistant Potato Starch Plus Deferasirox to Improve Outcomes in Patients Undergoing Allogeneic Stem Cell Transplantation
Led by University of Michigan Rogel Cancer Center · Updated on 2025-11-28
50
Participants Needed
1
Research Sites
206 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study will evaluate the safety and early efficacy of administering the combination of a commercially available potato-based resistant starch along with iron chelation therapy to subjects undergoing alloHCT.
CONDITIONS
Official Title
Phase II Study of Resistant Potato Starch Plus Deferasirox to Improve Outcomes in Patients Undergoing Allogeneic Stem Cell Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with hematologic disorders undergoing allo-HCT from fully HLA-matched unrelated or related donors after full-intensity conditioning regimen
- Age 18 years or older
- Karnofsky performance status greater than 70%
- Patients must be able to swallow capsules or tablets
- Ability to understand and willingness to sign informed consent
- Availability of a full-HLA matched donor medically eligible to donate cells according to National Marrow Donor Program criteria
You will not qualify if you...
- Active inflammatory bowel disease requiring treatment
- History of gastric bypass surgery
- Active Clostridium difficile infection at enrollment
- Active iron deficiency anemia requiring treatment
- Iron overload receiving active deferasirox treatment
- Known hypersensitivity to deferasirox or components of Jadenu or Exjade
- Currently enrolled or in follow-up on any other GVHD prevention trial
- Any physical or psychological condition posing unacceptable risk or concern for protocol compliance
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, United States, 48187
Actively Recruiting
Research Team
M
Mary Riwes
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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