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A Phase I/II Clinical Trial of ICP-723 in the Treatment of Advanced Solid Tumors
Led by Beijing InnoCare Pharma Tech Co., Ltd. · Updated on 2025-09-02
310
Participants Needed
24
Research Sites
386 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A Multicenter, Nonrandomized, Open-Label Phase I/IIClinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of ICP-723 in Patients with Solid Tumors
CONDITIONS
Official Title
A Phase I/II Clinical Trial of ICP-723 in the Treatment of Advanced Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histopathologically confirmed surgically unresectable locally advanced or metastatic solid tumors or primary central nervous system (CNS) tumors.
- Age 18 years or older for adults; ages 12 to less than 18 years for adolescents.
- At least one measurable lesion as per RECIST1.1 criteria, or for CNS tumors, measurable lesion per RANO or INRC criteria.
- ECOG Performance Status score of 0-1 for adults.
- Karnofsky (for age ≥ 16 years) or Lansky (for age < 16 years) Performance Status score above 60 for adolescents.
- Life expectancy greater than 3 months.
- Willingness to use medically acceptable effective birth control methods during the study and for 12 weeks after last dose if of childbearing potential.
- Signed informed consent form and agreement to follow treatment and visit schedule.
You will not qualify if you...
- Any other active cancer within 5 years before the first dose of study drug.
- Anti-cancer treatment within 28 days before the first dose.
- Major surgery within 4 weeks or minor surgery within 2 weeks before the first dose.
- History of allergic disease, severe drug allergy, or known hypersensitivity to any component of ICP-723.
- Any other condition judged by the investigator to make the subject unsuitable for the study.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 24 locations
1
The Second Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China, 230000
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2
Peking University Cancer Hospital
Beijing, Beijing Municipality, China, 100081
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3
The First Medical Center of the Chinese People's Liberation Army General Hospital
Beijing, Beijing Municipality, China, 100081
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4
Cancer Hospital Affiliated to Guangzhou Medical University
Guangzhou, Guangdong, China, 510000
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5
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China, 510000
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6
The Fifth Affiliated Hospital of Sun Yat-sen University
Zhuhai, Guangdong, China, 519000
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7
Sun Yat-Sen University Cancer Center
Guangdong, Guangzhou, China, 510060
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8
Shijiazhuang People's Hospital
Shijiazhuang, Hebei, China, 050000
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9
Cancer Hospital Affiliated to Harbin Medical University
Harbin, Heilongjiang, China, 150000
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10
The First Affiliated Hospital of Henan University of Science and Technology
Luoyang, Henan, China, 471000
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11
Henan Cancer Hospital
Zhengzhou, Henan, China, 450000
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12
Henan Provincial People's Hospital
Zhengzhou, Henan, China, 450000
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13
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450000
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14
Union Hospital, Tongji Medical College,Huazhong University of Science and Technology
Wuhan, Hubei, China, 430000
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15
Hunan Cancer hospital
Changsha, Hunan, China, 410000
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16
Jiangsu Provincial People's Hospital
Nanjing, Jiangsu, China, 210000
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17
Affiliated Hospital of Jiangnan University
Wuxi, Jiangsu, China, 214000
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18
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China, 330000
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19
Affiliated Cancer Hospital of Shandong First Medical University
Jinan, Shandong, China
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20
Affiliated Hospital of Qingdao University
Qingdao, Shandong, China, 266000
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21
Shanxi Cancer Hospital
Taiyuan, Shanxi, China, 030000
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22
Yunnan Cancer Hospital
Kunming, Yunnan, China, 650000
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23
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China, ,310000
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24
The first affiliated hospital Zhejiang university school of medicine
Hangzhou, Zhejiang, China, 310003
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Research Team
R
Rui Hua Xu, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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