Actively Recruiting
Led by AstraZeneca · Updated on 2026-05-18
675
Participants Needed
281
Research Sites
N/A
Total Duration
A
AstraZeneca
Lead Sponsor
D
Daiichi Sankyo
Collaborating Sponsor
Researchers are evaluating the effectiveness and safety of Datopotamab Deruxtecan (Dato-DXd) combined with rilvegostomig or rilvegostomig alone, compared to pembrolizumab alone, as first-line treatments for adults with locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) who have high PD-L1 expression (tumor cell 50% or greater) and no actionable genomic alterations. This Phase III, randomized, open-label global study aims to improve treatment options for this patient group. Participants will be randomly assigned to one of three groups: one receiving Dato-DXd plus rilvegostomig, another receiving rilvegostomig alone, and the third receiving pembrolizumab alone. All treatments are given as intravenous infusions every three weeks on the first day of each 21-day cycle. The study compares these therapies to see which is more effective and safe as a first-line treatment. During the study, participants will undergo regular assessments including tumor evaluations, biomarker testing, and symptom questionnaires. Researchers will monitor progression-free survival and overall survival over approximately four to six years, along with other measures such as response rate, duration of response, physical functioning, and quality of life. Safety and pharmacokinetics will also be evaluated to understand how the treatments affect participants over the long term.
CONDITIONS
Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to approximately 6 years
Participants receive intravenous infusions of study drugs every 3 weeks as first-line treatment for advanced non-squamous NSCLC with high PD-L1 expression.
Infusions every 3 weeks on Day 1 of each 21-day cycle
Total: 281 locations
1
Research Site
Anchorage, Alaska, United States, 99508
Actively Recruiting
2
Research Site
Tucson, Arizona, United States, 85719
Actively Recruiting
3
Research Site
Little Rock, Arkansas, United States, 72205
Actively Recruiting
4
Research Site
Springdale, Arkansas, United States, 72762
Actively Recruiting
5
Research Site
Anaheim, California, United States, 92801
Actively Recruiting
6
Research Site
Beverly Hills, California, United States, 90211
Actively Recruiting
7
Research Site
Fountain Valley, California, United States, 92708
Actively Recruiting
8
Research Site
Newport Beach, California, United States, 92663
Suspended
9
Research Site
Clermont, Florida, United States, 34711
Actively Recruiting
10
Research Site
Gainesville, Florida, United States, 32608
Actively Recruiting
11
Research Site
Miami Beach, Florida, United States, 33140
Actively Recruiting
12
Research Site
Orange City, Florida, United States, 32763
Actively Recruiting
13
Research Site
Orlando, Florida, United States, 32806
Actively Recruiting
14
Research Site
Orlando, Florida, United States, 32827
Withdrawn
15
Research Site
West Palm Beach, Florida, United States, 33401
Actively Recruiting
16
Research Site
Atlanta, Georgia, United States, 30303
Suspended
17
Research Site
Atlanta, Georgia, United States, 30318
Actively Recruiting
18
Research Site
Atlanta, Georgia, United States, 30322
Actively Recruiting
19
Research Site
Atlanta, Georgia, United States, 30342
Withdrawn
20
Research Site
Hinsdale, Illinois, United States, 60521
Actively Recruiting
21
Research Site
Noblesville, Indiana, United States, 46062
Actively Recruiting
22
Research Site
Paducah, Kentucky, United States, 42003
Not Yet Recruiting
23
Research Site
Annapolis, Maryland, United States, 21401
Actively Recruiting
24
Research Site
Boston, Massachusetts, United States, 02114
Actively Recruiting
25
Research Site
Boston, Massachusetts, United States, 02215
Actively Recruiting
26
Research Site
Dearborn, Michigan, United States, 48126
Actively Recruiting
27
Research Site
Farmington Hills, Michigan, United States, 48334
Actively Recruiting
28
Research Site
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
29
Research Site
Traverse City, Michigan, United States, 49684
Withdrawn
30
Research Site
Hattiesburg, Mississippi, United States, 39401
Actively Recruiting
31
Research Site
Kansas City, Missouri, United States, 64132
Actively Recruiting
32
Research Site
Bozeman, Montana, United States, 59715
Withdrawn
33
Research Site
Grand Island, Nebraska, United States, 68803
Actively Recruiting
34
Research Site
Omaha, Nebraska, United States, 68130
Actively Recruiting
35
Research Site
Las Vegas, Nevada, United States, 89102
Actively Recruiting
36
Research Site
Reno, Nevada, United States, 89502
Withdrawn
37
Research Site
Voorhees Township, New Jersey, United States, 08043
Suspended
38
Research Site
Stony Brook, New York, United States, 11794
Actively Recruiting
39
Research Site
Greenville, North Carolina, United States, 27834
Actively Recruiting
40
Research Site
Salisbury, North Carolina, United States, 28144
Actively Recruiting
41
Research Site
Cincinnati, Ohio, United States, 45219
Actively Recruiting
42
Research Site
Columbus, Ohio, United States, 43210
Withdrawn
43
Research Site
Maumee, Ohio, United States, 43537
Actively Recruiting
44
Research Site
Toledo, Ohio, United States, 43623
Actively Recruiting
45
Research Site
Portland, Oregon, United States, 97213
Withdrawn
46
Research Site
Greenville, South Carolina, United States, 29607
Actively Recruiting
47
Research Site
Sioux Falls, South Dakota, United States, 57105
Actively Recruiting
48
Research Site
Chattanooga, Tennessee, United States, 37404
Withdrawn
49
Research Site
Knoxville, Tennessee, United States, 37920
Withdrawn
50
Research Site
Fort Worth, Texas, United States, 76104
Actively Recruiting
51
Research Site
Houston, Texas, United States, 77030
Actively Recruiting
52
Research Site
Houston, Texas, United States, 77030
Withdrawn
53
Research Site
Houston, Texas, United States, 77090
Suspended
54
Research Site
Kingwood, Texas, United States, 77339
Actively Recruiting
55
Research Site
Odessa, Texas, United States, 79761
Actively Recruiting
56
Research Site
Fort Belvoir, Virginia, United States, 22060
Actively Recruiting
57
Research Site
Leesburg, Virginia, United States, 20176
Actively Recruiting
58
Research Site
Midlothian, Virginia, United States, 23114
Not Yet Recruiting
59
Research Site
Richmond, Virginia, United States, 23230
Actively Recruiting
60
Research Site
Tacoma, Washington, United States, 98405
Actively Recruiting
61
Research Site
Vancouver, Washington, United States, 98684
Actively Recruiting
62
Research Site
Wenatchee, Washington, United States, 98801
Actively Recruiting
63
Research Site
Appleton, Wisconsin, United States, 54911
Actively Recruiting
64
Research Site
Birtinya, Australia, 4575
Actively Recruiting
65
Research Site
Blacktown, Australia, 2148
Actively Recruiting
66
Research Site
Clayton, Australia, 3168
Actively Recruiting
67
Research Site
Gosford, Australia, 2250
Actively Recruiting
68
Research Site
Melbourne, Australia, 3000
Withdrawn
69
Research Site
South Brisbane, Australia, QL 4101
Actively Recruiting
70
Research Site
Wodonga, Australia, 3690
Actively Recruiting
71
Research Site
Innsbruck, Austria, 6020
Actively Recruiting
72
Research Site
Krems, Austria, 3500
Actively Recruiting
73
Research Site
Linz, Austria, 4020
Actively Recruiting
74
Research Site
Rankweil, Austria, 6830
Actively Recruiting
75
Research Site
Vienna, Austria, 1140
Actively Recruiting
76
Research Site
Vienna, Austria, 1210
Actively Recruiting
77
Research Site
Wels, Austria, 4600
Actively Recruiting
78
Research Site
Anderlecht, Belgium, 1070
Withdrawn
79
Research Site
Bruges, Belgium, 8000
Actively Recruiting
80
Research Site
Hasselt, Belgium, 3500
Actively Recruiting
81
Research Site
La Louvière, Belgium, 7100
Actively Recruiting
82
Research Site
Liège, Belgium, 4000
Actively Recruiting
83
Research Site
Barretos, Brazil, 14784-400
Actively Recruiting
84
Research Site
Curitiba, Brazil, 80730-150
Actively Recruiting
85
Research Site
Florianópolis, Brazil, 88034-000
Actively Recruiting
86
Research Site
Ipatinga, Brazil, 35162-189
Actively Recruiting
87
Research Site
Natal, Brazil, 59075-740
Actively Recruiting
88
Research Site
Porto Alegre, Brazil, 91350-200
Actively Recruiting
89
Research Site
Rio de Janeiro, Brazil, 22211-230
Actively Recruiting
90
Research Site
Santa Maria, Brazil, 97015-450
Actively Recruiting
91
Research Site
São Paulo, Brazil, 01221-020
Actively Recruiting
92
Research Site
Taubaté, Brazil, 12030-200
Actively Recruiting
93
Research Site
Vancouver, British Columbia, Canada, VSZ 4E6
Actively Recruiting
94
Research Site
Winnipeg, Manitoba, Canada, R3E 0V9
Withdrawn
95
Research Site
St. John's, Newfoundland and Labrador, Canada, A1B 3V6
Actively Recruiting
96
Research Site
London, Ontario, Canada, N6A 4L6
Actively Recruiting
97
Research Site
Newmarket, Ontario, Canada, L3Y 2P9
Withdrawn
98
Research Site
Oshawa, Ontario, Canada, L1G 2B9
Actively Recruiting
99
Research Site
Toronto, Ontario, Canada, M4N 3M5
Withdrawn
100
Research Site
Lévis, Quebec, Canada, G6V 0B8
Actively Recruiting
101
Research Site
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
102
Research Site
Montreal, Quebec, Canada, H3T 1M5
Actively Recruiting
103
Research Site
Montreal, Quebec, Canada, H4J 1C5
Actively Recruiting
104
Research Site
Rimouski, Quebec, Canada, G5L 5T1
Actively Recruiting
105
Research Site
Trois-Rivières, Quebec, Canada, G8Z 3R9
Actively Recruiting
106
Research Site
Saskatoon, Saskatchewan, Canada, S7N 4H4
Actively Recruiting
107
Research Site
Chicoutimi, Canada, G7H 5H6
Actively Recruiting
108
Research Site
Beijing, China, 100142
Actively Recruiting
109
Research Site
Beijing, China, 101149
Actively Recruiting
110
Research Site
Changchun, China, 130000
Not Yet Recruiting
111
Research Site
Changsha, China, 410013
Actively Recruiting
112
Research Site
Chengdu, China, 610000
Actively Recruiting
113
Research Site
Chengdu, China, 610041
Actively Recruiting
114
Research Site
Chongqing, China, 400030
Actively Recruiting
115
Research Site
Fuzhou, China, 350014
Actively Recruiting
116
Research Site
Guangzhou, China, 510080
Actively Recruiting
117
Research Site
Hangzhou, China, 310006
Actively Recruiting
118
Research Site
Hangzhou, China, 310016
Actively Recruiting
119
Research Site
Hangzhou, China, 310022
Actively Recruiting
120
Research Site
Harbin, China, 150049
Actively Recruiting
121
Research Site
Hefei, China, 230031
Withdrawn
122
Research Site
Hefei, China, 230601
Actively Recruiting
123
Research Site
Jinan, China, 250117
Actively Recruiting
124
Research Site
Jining, China, 272011
Actively Recruiting
125
Research Site
Kunming, China, 650118
Actively Recruiting
126
Research Site
Lanzhou, China, 730000
Actively Recruiting
127
Research Site
Linhai, China, 317000
Actively Recruiting
128
Research Site
Linyi, China, 276001
Actively Recruiting
129
Research Site
Nanjing, China, 210009
Actively Recruiting
130
Research Site
Nanning, China, 530000
Actively Recruiting
131
Research Site
Nanning, China, 530021
Actively Recruiting
132
Research Site
Shanghai, China, 200030
Actively Recruiting
133
Research Site
Shanghai, China, 200032
Actively Recruiting
134
Research Site
Shanghai, China, 200433
Actively Recruiting
135
Research Site
Shenyang, China, 110022
Actively Recruiting
136
Research Site
Taiyuan, China, 030000
Actively Recruiting
137
Research Site
Tianjin, China, 300060
Actively Recruiting
138
Research Site
Wenzhou, China, 325000
Actively Recruiting
139
Research Site
Wuhan, China, 430000
Actively Recruiting
140
Research Site
Wuhan, China, 430010
Actively Recruiting
141
Research Site
Wuhan, China, 430022
Actively Recruiting
142
Research Site
Wuhan, China, 430030
Actively Recruiting
143
Research Site
Xi'an, China, 710061
Actively Recruiting
144
Research Site
Yangzhou, China, 225001
Actively Recruiting
145
Research Site
Zhengzhou, China, 450000
Actively Recruiting
146
Research Site
Zhengzhou, China, 450008
Actively Recruiting
147
Research Site
Berlin, Germany, 10249
Not Yet Recruiting
148
Research Site
Bonn, Germany, 53113
Actively Recruiting
149
Research Site
Cologne, Germany, 50677
Actively Recruiting
150
Research Site
Düsseldorf, Germany, 40489
Withdrawn
151
Research Site
Essen, Germany, 45136
Actively Recruiting
152
Research Site
Freiburg im Breisgau, Germany, 79106
Actively Recruiting
153
Research Site
Gauting, Germany, 82131
Actively Recruiting
154
Research Site
Georgsmarienhütte, Germany, 49124
Actively Recruiting
155
Research Site
Gera, Germany, 07548
Withdrawn
156
Research Site
Gütersloh, Germany, 33332
Actively Recruiting
157
Research Site
Hamburg, Germany, 20251
Actively Recruiting
158
Research Site
Hamburg, Germany, 22087
Actively Recruiting
159
Research Site
Heidelberg, Germany, 69126
Actively Recruiting
160
Research Site
Kempten, Germany, 87439
Actively Recruiting
161
Research Site
Koblenz, Germany, 56068
Suspended
162
Research Site
Ludwigsburg, Germany, 71640
Withdrawn
163
Research Site
München, Germany, 81925
Not Yet Recruiting
164
Research Site
Nuremberg, Germany, 90419
Actively Recruiting
165
Research Site
Potsdam, Germany, 14467
Actively Recruiting
166
Research Site
Ravensburg, Germany, 88212
Actively Recruiting
167
Research Site
Budapest, Hungary, 1121
Actively Recruiting
168
Research Site
Gyöngyös, Hungary, 3200
Withdrawn
169
Research Site
Gyöngyös - Mátraháza, Hungary, 3200
Actively Recruiting
170
Research Site
Győr, Hungary, 9024
Actively Recruiting
171
Research Site
Gyula, Hungary, 5700
Not Yet Recruiting
172
Research Site
Kecskemét, Hungary, 6000
Actively Recruiting
173
Research Site
Salgótarján, Hungary, 3100
Actively Recruiting
174
Research Site
Szekszárd, Hungary, 7100
Actively Recruiting
175
Research Site
Székesfehérvár, Hungary, 8000
Actively Recruiting
176
Research Site
Törökbálint, Hungary, 2045
Actively Recruiting
177
Research Site
Chennai, India, 600031
Actively Recruiting
178
Research Site
Dwārka, India, 110075
Actively Recruiting
179
Research Site
Jaipur, India, 302004
Actively Recruiting
180
Research Site
Kolkata, India, 700099
Actively Recruiting
181
Research Site
Marg Jaipur, India, 302004
Withdrawn
182
Research Site
Nagpur, India, 440001
Actively Recruiting
183
Research Site
Nashik, India, 422011
Actively Recruiting
184
Research Site
New Delhi, India, 110085
Actively Recruiting
185
Research Site
New Delhi, India, 11029
Actively Recruiting
186
Research Site
Surat, India, 395002
Actively Recruiting
187
Research Site
Thiruvananthapuram, India, 695011
Actively Recruiting
188
Research Site
Bergamo, Italy, 24125
Actively Recruiting
189
Research Site
Genoa, Italy, 16132
Actively Recruiting
190
Research Site
Milan, Italy, 20141
Actively Recruiting
191
Research Site
Milan, Italy, 20162
Actively Recruiting
192
Research Site
Monza, Italy, 20052
Actively Recruiting
193
Research Site
Padova, Italy, 35128
Actively Recruiting
194
Research Site
Pavia, Italy, 27100
Actively Recruiting
195
Research Site
Ravenna, Italy, 48100
Actively Recruiting
196
Research Site
Roma, Italy, 00128
Actively Recruiting
197
Research Site
Rozzano, Italy, 20089
Actively Recruiting
198
Research Site
Bunkyō City, Japan, 113-8431
Actively Recruiting
199
Research Site
Bunkyō City, Japan, 160-0023
Actively Recruiting
200
Research Site
Fukuoka, Japan, 812-8582
Actively Recruiting
201
Research Site
Fukuoka, Japan, 814-0180
Actively Recruiting
202
Research Site
Hidaka-shi, Japan, 350-1298
Actively Recruiting
203
Research Site
Hirakata-shi, Japan, 573-1191
Actively Recruiting
204
Research Site
Hirosaki-shi, Japan, 036-8563
Actively Recruiting
205
Research Site
Hiroshima, Japan, 730-8518
Actively Recruiting
206
Research Site
Kanazawa, Japan, 920-8641
Actively Recruiting
207
Research Site
Kashiwa, Japan, 227-8577
Actively Recruiting
208
Research Site
Kawasaki-shi, Japan, 216-8511
Actively Recruiting
209
Research Site
Kumamoto, Japan, 860-8556
Actively Recruiting
210
Research Site
Matsusaka-shi, Japan, 515-8544
Not Yet Recruiting
211
Research Site
Nagoya, Japan, 460-0001
Actively Recruiting
212
Research Site
Niigata, Japan, 951-8566
Actively Recruiting
213
Research Site
Okayama, Japan, 700-8558
Actively Recruiting
214
Research Site
Osaka, Japan, 545-8586
Actively Recruiting
215
Research Site
Osakasayama-shi, Japan, 589-8511
Actively Recruiting
216
Research Site
Sagamihara-shi, Japan, 252-0375
Actively Recruiting
217
Research Site
Sapporo, Japan, 003-0804
Actively Recruiting
218
Research Site
Takaoka-shi, Japan, 933-8555
Actively Recruiting
219
Research Site
Takatsuki-shi, Japan, 569-8686
Actively Recruiting
220
Research Site
Tokushima, Japan, 770-8503
Actively Recruiting
221
Research Site
Tokyo, Japan, 104-0045
Actively Recruiting
222
Research Site
Utsunomiya, Japan, 320-0834
Actively Recruiting
223
Research Site
Yokohama, Japan, 221-0855
Actively Recruiting
224
Research Site
Olsztyn, Poland, 10-357
Actively Recruiting
225
Research Site
Poznan, Poland, 60-569
Actively Recruiting
226
Research Site
Przemyśl, Poland, 37-700
Actively Recruiting
227
Research Site
Warsaw, Poland, 01-138
Actively Recruiting
228
Research Site
Warsaw, Poland, 02-781
Actively Recruiting
229
Research Site
San Juan, Puerto Rico, 00909
Actively Recruiting
230
Research Site
Changwon, South Korea, 51353
Actively Recruiting
231
Research Site
Incheon, South Korea, 21565
Actively Recruiting
232
Research Site
Seongnam-si, South Korea, 13496
Actively Recruiting
233
Research Site
Seoul, South Korea, 03080
Actively Recruiting
234
Research Site
Seoul, South Korea, 03722
Actively Recruiting
235
Research Site
Suwon, South Korea, 16247
Actively Recruiting
236
Research Site
Suwon, South Korea, 16499
Actively Recruiting
237
Research Site
Alicante, Spain, 03010
Actively Recruiting
238
Research Site
Barcelona, Spain, 08003
Actively Recruiting
239
Research Site
Barcelona, Spain, 08036
Actively Recruiting
240
Research Site
Barcelona, Spain, 08041
Not Yet Recruiting
241
Research Site
Jerez de la Frontera, Spain, 11407
Actively Recruiting
242
Research Site
Reus, Spain, 43204
Actively Recruiting
243
Research Site
Salamanca, Spain, 37007
Withdrawn
244
Research Site
Kaohsiung City, Taiwan, 80756
Actively Recruiting
245
Research Site
New Taipei City, Taiwan, 220
Actively Recruiting
246
Research Site
Taichung, Taiwan, 40447
Actively Recruiting
247
Research Site
Taichung, Taiwan, 40705
Actively Recruiting
248
Research Site
Tainan, Taiwan, 704
Actively Recruiting
249
Research Site
Taipei, Taiwan, 0116
Actively Recruiting
250
Research Site
Taipei, Taiwan, 10002
Actively Recruiting
251
Research Site
Taipei, Taiwan, 112
Actively Recruiting
252
Research Site
Taipei, Taiwan, TAIWAN
Actively Recruiting
253
Research Site
Taoyuan, Taiwan, 333
Actively Recruiting
254
Research Site
Bangkok, Thailand, 10400
Actively Recruiting
255
Research Site
Hat Yai, Thailand, 90110
Actively Recruiting
256
Research Site
Muang, Thailand, 22000
Actively Recruiting
257
Research Site
Mueang, Thailand, 20000
Actively Recruiting
258
Research Site
Mueang, Thailand, 32000
Actively Recruiting
259
Research Site
Adapazarı, Turkey (Türkiye), 54100
Actively Recruiting
260
Research Site
Ankara, Turkey (Türkiye), 06560
Actively Recruiting
261
Research Site
Ankara, Turkey (Türkiye), 6200
Actively Recruiting
262
Research Site
Antalya, Turkey (Türkiye), 07070
Actively Recruiting
263
Research Site
Diyarbakır, Turkey (Türkiye), 21280
Actively Recruiting
264
Research Site
Istanbul, Turkey (Türkiye), 34030
Actively Recruiting
265
Research Site
Istanbul, Turkey (Türkiye), 34890
Actively Recruiting
266
Research Site
Cheltenham, United Kingdom, GL53 7AN
Suspended
267
Research Site
Inverness, United Kingdom, IV2 3UJ
Suspended
268
Research Site
London, United Kingdom, SE1 9RT
Withdrawn
269
Research Site
London, United Kingdom, SW10 9NH
Actively Recruiting
270
Research Site
London, United Kingdom, SW17 0QT
Actively Recruiting
271
Research Site
Norwich, United Kingdom, NR4 7UY
Not Yet Recruiting
272
Research Site
Preston, United Kingdom, PR2 9HT
Actively Recruiting
273
Research Site
Truro, United Kingdom, TR1 3LJ
Actively Recruiting
274
Research Site
Da Nang, Vietnam, 550000
Actively Recruiting
275
Research Site
Hanoi, Vietnam, 100000
Actively Recruiting
276
Research Site
Hà Nội, Vietnam, 100000
Actively Recruiting
277
Research Site
Ho Chi Minh City, Vietnam, 700000
Actively Recruiting
278
Research Site
Ho Chi Minh City, Vietnam, 700000
Withdrawn
279
Research Site
Huế, Vietnam, 530000
Withdrawn
280
Research Site
Vinh, Vietnam, 460000
Withdrawn
281
Research Site
Vĩnh Yên, Vietnam, 280000
Actively Recruiting
A
AstraZeneca Clinical Study Information Center
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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Thomas Newsom-Davis, Barbara Melosky, Rebecca S Heist...
https://pubmed.ncbi.nlm.nih.gov/41669261