Actively Recruiting
A Phase III Study of HMPL-760 Plus R-GemOx VS Placebo Plus R-GemOx in Relapsed/Refractory DLBCL
Led by Hutchmed · Updated on 2026-04-01
240
Participants Needed
41
Research Sites
145 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a Phase III randomized, double-blind, positive controlled study to evaluate the efficacy, safety, and pharmacokinetics of HMPL-760 in combination with R-GemOx versus placebo in combination with R-GemOx in patients with R/R DLBCL.
CONDITIONS
Official Title
A Phase III Study of HMPL-760 Plus R-GemOx VS Placebo Plus R-GemOx in Relapsed/Refractory DLBCL
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent and able to follow study protocol requirements
- Age 18 years or older
- ECOG performance status score between 0 and 2
- Confirmed diagnosis of Diffuse Large B-Cell Lymphoma (DLBCL) by histopathology
- Investigator judges further treatment is needed
- At least one measurable lesion by two dimensions
- Expected survival longer than 12 weeks
You will not qualify if you...
- Known primary or secondary central nervous system lymphoma (CNSL) or symptoms suggesting CNSL
- Pregnant or breastfeeding women
- Organ insufficiency
- History of liver disease including cirrhosis, alcoholic liver disease, or active infection with HIV, HBV, or HCV
- Significant organ bleeding within 8 weeks before study drug start
- Known bleeding risks such as coagulation factor deficiency, vascular hemophilia, or current use of warfarin
- Toxic effects from previous anti-tumor therapy not recovered to grade 1 or better (except alopecia and decreased appetite as specified)
- Clinically significant active infection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 41 locations
1
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China
Not Yet Recruiting
2
Baoding NO.1 Central Hospital
Baoding, China
Not Yet Recruiting
3
Beijing GoBroad Hospital
Beijing, China
Not Yet Recruiting
4
BEIJING TONGREN HOSPITAL, Capital Medical University
Beijing, China
Not Yet Recruiting
5
The First Affiliated Hospital of Bengbu Medical College
Bengbu, China
Not Yet Recruiting
6
The First Hospital of Jilin University
Changchun, China
Not Yet Recruiting
7
Hunan Cancer Hospital
Changsha, China
Not Yet Recruiting
8
People's Hospital of Hunan Province
Changsha, China
Not Yet Recruiting
9
The Second Xiangya Hospital of Central South University
Changsha, China
Not Yet Recruiting
10
Sichuan Provincial People's Hospital
Chengdu, China
Not Yet Recruiting
11
West China Hospital of Sichuan University
Chengdu, China
Not Yet Recruiting
12
Chongqing University Cancer Hospital
Chongqing, China
Not Yet Recruiting
13
Quanzhou First Hospital.Fujian
Fujian, China
Not Yet Recruiting
14
Fujian Medical University Union Hospital
Fuzhou, China
Not Yet Recruiting
15
Sun Yat-sen University Cancer Center
Guangzhou, China
Not Yet Recruiting
16
ZhuJiang Hospital of Southern Medical University（The Second Clinical Medical College）
Guangzhou, China
Not Yet Recruiting
17
The Affiliated Hospital of Guizhou Medical University
Guiyang, China
Not Yet Recruiting
18
The First Affiliated Hospital, Zhejiang University
Hangzhou, China
Not Yet Recruiting
19
Zhejiang Cancer Hospital
Hangzhou, China
Not Yet Recruiting
20
Harbin Medical University Cancer Hospital
Harbin, China
Not Yet Recruiting
21
The Second Affiliated Hospital of Anhui Medical University
Hefei, China
Not Yet Recruiting
22
Qilu Hospital of Shandong University
Jinan, China
Not Yet Recruiting
23
Shandong Cancer Hospital & Institute
Jinan, China
Not Yet Recruiting
24
Jiangxi Cancer Hospital
Nanchang, China
Not Yet Recruiting
25
Jiangsu Cancer Hospital
Nanjing, China
Not Yet Recruiting
26
The First Affiliated Hospital of Guangxi Medical University
Nanning, China
Not Yet Recruiting
27
The Affiliated Hospital of Qingdao University
Qingdao, China
Not Yet Recruiting
28
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, China
Not Yet Recruiting
29
Tongji Hospital of Tongji University
Shanghai, China
Not Yet Recruiting
30
Shengjing Hospital of China Medical University
Shenyang, China
Not Yet Recruiting
31
Shanxi Provincial Cancer Hospitial
Taiyuan, China
Not Yet Recruiting
32
North China University of Science and Technology Affiliated Hospital
Tangshan, China
Not Yet Recruiting
33
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Tianjin, China
Actively Recruiting
34
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China
Not Yet Recruiting
35
Tianjin People's Hospital
Tianjin, China
Not Yet Recruiting
36
Cancer Hospital Affiliated to Xinjiang Medical University
Ürümqi, China
Not Yet Recruiting
37
Hubei Cancer Hospital
Wuhan, China
Not Yet Recruiting
38
Wuhan Union Hospital of China
Wuhan, China
Not Yet Recruiting
39
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China
Not Yet Recruiting
40
Henan Cancer Hospital
Zhengzhou, China
Not Yet Recruiting
41
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, China
Not Yet Recruiting
Research Team
D
Dongmei Chen, CPL
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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