Actively Recruiting
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
Led by Summit Therapeutics · Updated on 2026-05-05
600
Participants Needed
76
Research Sites
210 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with mFOLFOX6 (Oxaliplatin, Leucovorin and 5-Fluorouracil) versus Bevacizumab in Combination with FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer(HARMONi-GI3)
CONDITIONS
Official Title
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ECOG performance status score of 0 or 1
- Expected life expectancy 65 6 months
- Histologically or cytologically confirmed metastatic colorectal cancer
- No prior systemic therapy for metastatic colorectal cancer
- At least 1 measurable noncerebral lesion
You will not qualify if you...
- Microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) disease
- Known BRAF V600E mutant status
- Significant radiographic or clinical gastrointestinal obstruction
- Ascites requiring paracentesis within last 30 days
- Prior immunotherapy or anti-angiogenic therapy for colorectal cancer
- Active or prior history of inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis, chronic diarrhea)
- Resectable disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 76 locations
1
Clinical Study Site
Goodyear, Arizona, United States, 85338
Actively Recruiting
2
Clinical Study Site
Beverly Hills, California, United States, 90211
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3
Clinical Study Site
Beverly Hills, California, United States, 90212
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4
Clinical Study Site
Cerritos, California, United States, 90703
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5
Clinical Study Site
Corona, California, United States, 92882
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6
Clinical Study Site
Duarte, California, United States, 91010
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7
Clinical Study Site
Fountain Valley, California, United States, 92708
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8
Clinical Study Site
Huntington Beach, California, United States, 92648
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9
Clinical Study Site
Irvine, California, United States, 92612
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10
Clinical Study Site
Irvine, California, United States, 92618
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11
Clinical Study Site
Los Angeles, California, United States, 90027
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12
Clinical Study Site
Los Angeles, California, United States, 90067
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13
Clinical Study Site
Los Angeles, California, United States, 90404
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14
Clinical Study Site
Murrieta, California, United States, 92562
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15
Clinical Study Site
Orange, California, United States, 92868
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16
Clinical Study Site
Pasadena, California, United States, 91030
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17
Clinical Study Site
Torrance, California, United States, 90503
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18
Clinical Study Site
Upland, California, United States, 91786
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19
Clinical Study Site
West Hollywood, California, United States, 90048
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20
Clinical Study Site
Hartford, Connecticut, United States, 06106
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21
Clinical Study Site
New Haven, Connecticut, United States, 06520-8028
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22
Clinical Study Site
Norwich, Connecticut, United States, 06360
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23
Clinical Study Site
Hialeah, Florida, United States, 33013
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24
Clinical Study Site
Miami, Florida, United States, 33176
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25
Clinical Study Site
Orlando, Florida, United States, 32806
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26
Clinical Study Site
Plantation, Florida, United States, 33322
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27
Clinical Study Site
Port Saint Lucie, Florida, United States, 34952
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28
Clinical Study Site
Tamarac, Florida, United States, 33321
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29
Clinical Study Site
Newnan, Georgia, United States, 30265
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30
Clinical Study Site
Chicago, Illinois, United States, 60611
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31
Clinical Study Site
Elmhurst, Illinois, United States, 60540
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32
Clinical Study Site
O'Fallon, Illinois, United States, 62269
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33
Clinical Study Site
Fort Wayne, Indiana, United States, 46804
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34
Clinical Study Site
Indianapolis, Indiana, United States, 46202
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35
Clinical Study Site
Edgewood, Kentucky, United States, 41017
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36
Clinical Study Site
Saint Louis Park, Minnesota, United States, 55426
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37
Clinical Study Site
Billings, Montana, United States, 59102
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38
Clinical Study Site
Lincoln, Nebraska, United States, 68506
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39
Clinical Study Site
New Brunswick, New Jersey, United States, 08901
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40
Clinical Study Site
Mineola, New York, United States, 11501
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41
Clinical Study Site
New York, New York, United States, 10016
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42
Clinical Study Site
The Bronx, New York, United States, 10461
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43
Clinical Study Site
Akron, Ohio, United States, 44032
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44
Clinical Study Site
Canton, Ohio, United States, 44703
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45
Clinical Study Site
Cincinnati, Ohio, United States, 45219
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46
Clinical Study Site
Cincinnati, Ohio, United States, 45220
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47
Clinical Study Site
Cleveland, Ohio, United States, 44111
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48
Clinical Study Site
Cleveland, Ohio, United States, 44195
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49
Clinical Study Site
Mayfield Heights, Ohio, United States, 44124
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50
Clinical Study Site
Philadelphia, Pennsylvania, United States, 19111
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51
Clinical Study Site
Philadelphia, Pennsylvania, United States, 19140
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52
Clinical Study Site
Hermitage, Tennessee, United States, 37129
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53
Clinical Study Site
Fort Worth, Texas, United States, 76104
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54
Clinical Study Site
Salt Lake City, Utah, United States, 84106
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55
Clinical Study Site
Charlottesville, Virginia, United States, 22908
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56
Clinical Study Site
Spokane, Washington, United States, 99208
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57
Clinical Study Site
Tacoma, Washington, United States, 98405
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58
Clinical Study Site
Charleston, West Virginia, United States, 25304
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59
Clinical Study Site
Montreal, Quebec, Canada, H4A 3J1
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60
Clinical Study Site
Aichi, Japan, 464-8681
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61
Clinical Study Site
Chiba, Japan, 260-8717
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62
Clinical Study Site
Fukuoka, Japan, 812-8582
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63
Clinical Study Site
Gifu, Japan, 501-1194
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64
Clinical Study Site
Hiroshima, Japan, 734-8551
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65
Clinical Study Site
Hokkaido, Japan, 060-8648
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66
Clinical Study Site
Kawasaki, Japan, 216-8511
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67
Clinical Study Site
Osaka, Japan, 541-8567
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68
Clinical Study Site
Sendai, Japan, 980-0872
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69
Clinical Study Site
Shizuoka, Japan, 411-8777
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70
Clinical Study Site
Tokyo, Japan, 104-0045
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71
Clinical Study Site
Tokyo, Japan, 135-8550
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72
Clinical Study Site
Toyama, Japan, 930-0194
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73
Clinical Study Site
Rio Piedras, Puerto Rico, 00935
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74
Clinical Study Site
Canterbury, England, United Kingdom, CT13NS
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75
Clinical Study Site
London, England, United Kingdom, EC1M 6BQ
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76
Clinical Study Site
Aberdeen, Scotland, United Kingdom, AB25 2ZN
Actively Recruiting
Research Team
N
Nindhana Paranthaman, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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