Actively Recruiting
Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
Led by AstraZeneca · Updated on 2026-05-11
1220
Participants Needed
217
Research Sites
253 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a Phase III, randomised, open-label, sponsor-blinded, 3-arm, multicentre, global study assessing the efficacy and safety of rilvegostomig in combination with bevacizumab with or without tremelimumab compared to atezolizumab in combination with bevacizumab. This study will be conducted in participants with advanced HCC who are not amenable to curative therapy or locoregional therapy
CONDITIONS
Official Title
Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Locally advanced or metastatic and/or unresectable hepatocellular carcinoma
- WHO/ECOG performance status of 0 or 1
- BCLC stage B (not eligible for locoregional therapy) or stage C
- Child-Pugh Score class A
- At least one measurable target lesion
- Participants with active HBV infection must have received antiviral therapy for at least 14 days before randomization showing viral stabilization or response
- Participants with active HCV infection must have well-controlled infection
- Participants co-infected with HBV and HCV are not eligible
- Adequate organ and bone marrow function during screening
- No prior systemic therapy for intermediate, advanced, or metastatic HCC
- Disease not suitable for curative surgical or locoregional therapies; if prior locoregional therapy, it must have been completed at least 28 days before baseline scan
You will not qualify if you...
- Evidence of uncontrolled intercurrent diseases
- Active or prior autoimmune or inflammatory disorders needing chronic steroids or immunosuppressive treatment
- History of another primary malignancy
- Persistent toxicities from previous anti-cancer therapy worse than Grade 1 or baseline, except alopecia
- Clinically meaningful ascites, pleural effusion, or pericardial effusion requiring non-drug intervention within 6 months before first dose
- History of active primary immunodeficiency or active infection
- History of hepatic encephalopathy
- Current or recent (within 10 days) use of aspirin ≥325 mg/day or certain antiplatelet drugs
- Current or recent (within 10 days) use of full-dose oral or parenteral anticoagulants or thrombolytics for treatment purposes
- History of significant bleeding disorders, vasculitis, or major gastrointestinal bleeding within 6 months before randomization
- Untreated or incompletely treated varices with bleeding or high risk of bleeding
- Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC
- Central nervous system metastases or spinal cord compression
- Prior treatment with anti-CTLA-4 or anti-TIGIT therapies
- Radiotherapy within 28 days, or abdominal/pelvic radiotherapy within 60 days before study treatment start, except palliative bone radiotherapy within 7 days
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 217 locations
1
Research Site
Phoenix, Arizona, United States, 85054
Actively Recruiting
2
Research Site
Tucson, Arizona, United States, 85719
Not Yet Recruiting
3
Research Site
Palo Alto, California, United States, 94304
Actively Recruiting
4
Research Site
Santa Monica, California, United States, 90404
Not Yet Recruiting
5
Research Site
New Haven, Connecticut, United States, 06511
Actively Recruiting
6
Research Site
Newark, Delaware, United States, 19713
Not Yet Recruiting
7
Research Site
Jacksonville, Florida, United States, 32224
Actively Recruiting
8
Research Site
Atlanta, Georgia, United States, 30318
Not Yet Recruiting
9
Research Site
Atlanta, Georgia, United States, 30322
Withdrawn
10
Research Site
Chicago, Illinois, United States, 60637
Not Yet Recruiting
11
Research Site
Indianapolis, Indiana, United States, 46202
Not Yet Recruiting
12
Research Site
Shreveport, Louisiana, United States, 71103
Not Yet Recruiting
13
Research Site
Detroit, Michigan, United States, 48202
Not Yet Recruiting
14
Research Site
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
15
Research Site
Rochester, Minnesota, United States, 55905
Actively Recruiting
16
Research Site
New Brunswick, New Jersey, United States, 08901
Actively Recruiting
17
Research Site
New York, New York, United States, 10029
Actively Recruiting
18
Research Site
New York, New York, United States, 10032
Not Yet Recruiting
19
Research Site
New York, New York, United States, 10065
Not Yet Recruiting
20
Research Site
Cleveland, Ohio, United States, 44195
Withdrawn
21
Research Site
Philadelphia, Pennsylvania, United States, 19107
Not Yet Recruiting
22
Research Site
Pittsburgh, Pennsylvania, United States, 15232
Not Yet Recruiting
23
Research Site
Austin, Texas, United States, 78705
Actively Recruiting
24
Research Site
Dallas, Texas, United States, 75390
Withdrawn
25
Research Site
El Paso, Texas, United States, 79902
Not Yet Recruiting
26
Research Site
Houston, Texas, United States, 77030
Not Yet Recruiting
27
Research Site
San Antonio, Texas, United States, 78240
Actively Recruiting
28
Research Site
Tyler, Texas, United States, 75702
Not Yet Recruiting
29
Research Site
Arlington, Virginia, United States, 22201
Not Yet Recruiting
30
Research Site
Salem, Virginia, United States, 24153
Actively Recruiting
31
Research Site
Seattle, Washington, United States, 98109
Not Yet Recruiting
32
Research Site
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
33
Research Site
Auchenflower, Australia, 4066
Actively Recruiting
34
Research Site
Camperdown, Australia, 2050
Actively Recruiting
35
Research Site
Clayton, Australia, 3168
Not Yet Recruiting
36
Research Site
Heidelberg, Australia, 3084
Actively Recruiting
37
Research Site
Barretos, Brazil, 14784-400
Not Yet Recruiting
38
Research Site
Porto Alegre, Brazil, 91350-200
Actively Recruiting
39
Research Site
Santa Maria, Brazil, 97015-450
Actively Recruiting
40
Research Site
São Paulo, Brazil, 04014-002
Actively Recruiting
41
Research Site
São Paulo, Brazil, 05652-9000
Actively Recruiting
42
Research Site
Vitória, Brazil, 29043-272
Actively Recruiting
43
Research Site
Edmonton, Alberta, Canada, T6G 1Z2
Not Yet Recruiting
44
Research Site
Halifax, Nova Scotia, Canada, B3H 1V7
Not Yet Recruiting
45
Research Site
Barrie, Ontario, Canada, L4M 6M2
Actively Recruiting
46
Research Site
Brampton, Ontario, Canada, L6R 3J7
Not Yet Recruiting
47
Research Site
Cambridge, Ontario, Canada, N1R 3G2
Not Yet Recruiting
48
Research Site
Ottawa, Ontario, Canada, K1H 8L6
Withdrawn
49
Research Site
Toronto, Ontario, Canada, M5G 1X6
Actively Recruiting
50
Research Site
Montreal, Quebec, Canada, H2X 0A9
Actively Recruiting
51
Research Site
Québec, Quebec, Canada, G1J 1Z4
Actively Recruiting
52
Research Site
Beijing, China, 100034
Not Yet Recruiting
53
Research Site
Beijing, China, 100142
Not Yet Recruiting
54
Research Site
Beijing, China, CN-100730
Not Yet Recruiting
55
Research Site
Changchun, China, 130021
Not Yet Recruiting
56
Research Site
Changsha, China, 410013
Not Yet Recruiting
57
Research Site
Chengdu, China, 610041
Not Yet Recruiting
58
Research Site
Chengdu, China, 610041
Actively Recruiting
59
Research Site
Chifeng, China, 024000
Not Yet Recruiting
60
Research Site
Chongqing, China, 400010
Not Yet Recruiting
61
Research Site
Deyang, China, 618000
Actively Recruiting
62
Research Site
Fuzhou, China, 350005
Not Yet Recruiting
63
Research Site
Guangzhou, China, 510060
Not Yet Recruiting
64
Research Site
Guangzhou, China, 510515
Actively Recruiting
65
Research Site
Guiyang, China, 550002
Actively Recruiting
66
Research Site
Harbin, China, 150081
Actively Recruiting
67
Research Site
Hefei, China, 230022
Actively Recruiting
68
Research Site
Hohhot, China, 010020
Not Yet Recruiting
69
Research Site
Kunming, China, 650118
Not Yet Recruiting
70
Research Site
Linyi, China, 276000
Actively Recruiting
71
Research Site
Lishui, China, 323000
Actively Recruiting
72
Research Site
Luoyang, China, 471000
Actively Recruiting
73
Research Site
Nanchang, China, 330008
Actively Recruiting
74
Research Site
Nanchang, China, 330029
Not Yet Recruiting
75
Research Site
Nanjing, China, 210029
Not Yet Recruiting
76
Research Site
Nanning, China, 530021
Actively Recruiting
77
Research Site
Nantong, China, 226361
Actively Recruiting
78
Research Site
Neijiang, China, 641100
Not Yet Recruiting
79
Research Site
Shandong, China
Not Yet Recruiting
80
Research Site
Shanghai, China, 201114
Actively Recruiting
81
Research Site
Shenyang, China, 110004
Not Yet Recruiting
82
Research Site
Shenyang, China, 110042
Not Yet Recruiting
83
Research Site
Weifang, China, 261000
Not Yet Recruiting
84
Research Site
Wenzhou, China, 325000
Actively Recruiting
85
Research Site
Wuhan, China, 430079
Not Yet Recruiting
86
Research Site
Xi'an, China, 710100
Not Yet Recruiting
87
Research Site
Zhengzhou, China, 450008
Not Yet Recruiting
88
Research Site
Clichy, France, 92118
Not Yet Recruiting
89
Research Site
Lille, France, 59000
Not Yet Recruiting
90
Research Site
Lyon, France, 69317
Actively Recruiting
91
Research Site
Nantes, France, 44093
Not Yet Recruiting
92
Research Site
Nice, France, 06200
Not Yet Recruiting
93
Research Site
Pessac, France, 33604
Actively Recruiting
94
Research Site
Rennes, France, 35000
Not Yet Recruiting
95
Research Site
Toulouse, France, 31059
Not Yet Recruiting
96
Research Site
Aachen, Germany, 52074
Actively Recruiting
97
Research Site
Berlin, Germany, 13353
Not Yet Recruiting
98
Research Site
Bonn, Germany, 53127
Actively Recruiting
99
Research Site
Dortmund, Germany, 44137
Actively Recruiting
100
Research Site
Dresden, Germany, 01307
Actively Recruiting
101
Research Site
Essen, Germany, 45122
Not Yet Recruiting
102
Research Site
Frankfurt, Germany, 60488
Actively Recruiting
103
Research Site
Frankfurt, Germany, 60590
Actively Recruiting
104
Research Site
Göttingen, Germany, 37075
Suspended
105
Research Site
Hamburg, Germany, 20246
Not Yet Recruiting
106
Research Site
Hanover, Germany, 30623
Actively Recruiting
107
Research Site
Leipzig, Germany, 4103
Not Yet Recruiting
108
Research Site
Lübeck, Germany, 23538
Not Yet Recruiting
109
Research Site
Magdeburg, Germany, 39120
Actively Recruiting
110
Research Site
Moers, Germany, 47441
Actively Recruiting
111
Research Site
München, Germany, 81377
Not Yet Recruiting
112
Research Site
Regensburg, Germany, 93053
Withdrawn
113
Research Site
Ulm, Germany, 89081
Not Yet Recruiting
114
Research Site
Hong Kong, Hong Kong, 999077
Actively Recruiting
115
Research Site
Shatin, Hong Kong, 00000
Actively Recruiting
116
Research Site
Ahmedabad, India, 380058
Not Yet Recruiting
117
Research Site
Bangalore, India, 560027
Withdrawn
118
Research Site
Binnāguri, India, 734015
Not Yet Recruiting
119
Research Site
Dehradun, India, 248016
Not Yet Recruiting
120
Research Site
Delhi, India, 110029
Not Yet Recruiting
121
Research Site
Hyderabad, India, 500032
Not Yet Recruiting
122
Research Site
Mumbai, India, 400012
Not Yet Recruiting
123
Research Site
Nashik, India, 422011
Not Yet Recruiting
124
Research Site
Vadodara, India, 391760
Not Yet Recruiting
125
Research Site
Bologna, Italy, 40138
Actively Recruiting
126
Research Site
Milan, Italy, 20132
Actively Recruiting
127
Research Site
Milan, Italy, 20162
Not Yet Recruiting
128
Research Site
Palermo, Italy, 90127
Not Yet Recruiting
129
Research Site
Perugia, Italy, 06132
Not Yet Recruiting
130
Research Site
Pisa, Italy, 56126
Actively Recruiting
131
Research Site
Roma, Italy, 00168
Not Yet Recruiting
132
Research Site
Rozzano, Italy, 20089
Actively Recruiting
133
Research Site
Bunkyō City, Japan, 113-8655
Actively Recruiting
134
Research Site
Chiba, Japan, 260-8677
Actively Recruiting
135
Research Site
Fukuoka, Japan, 811-1395
Actively Recruiting
136
Research Site
Hiroshima, Japan, 734-8530
Actively Recruiting
137
Research Site
Hiroshima, Japan, 734-8551
Actively Recruiting
138
Research Site
Iizuka-shi, Japan, 820-8505
Actively Recruiting
139
Research Site
Kashiwa, Japan, 227-8577
Actively Recruiting
140
Research Site
Kita-gun, Japan, 761-0793
Actively Recruiting
141
Research Site
Kobe, Japan, 650-0017
Actively Recruiting
142
Research Site
Kōtoku, Japan, 135-8550
Actively Recruiting
143
Research Site
Kumamoto, Japan, 860-8556
Actively Recruiting
144
Research Site
Kurume-shi, Japan, 830-0011
Actively Recruiting
145
Research Site
Kyoto, Japan, 602-8566
Actively Recruiting
146
Research Site
Matsuyama, Japan, 790-0024
Actively Recruiting
147
Research Site
Mitaka-shi, Japan, 181-8611
Actively Recruiting
148
Research Site
Morioka, Japan, 028-3695
Actively Recruiting
149
Research Site
Musashino-shi, Japan, 180-8610
Actively Recruiting
150
Research Site
Nagoya, Japan, 464-8681
Actively Recruiting
151
Research Site
Okayama, Japan, 700-8558
Actively Recruiting
152
Research Site
Osaka, Japan, 541-8567
Actively Recruiting
153
Research Site
Osakasayama-shi, Japan, 589-8511
Actively Recruiting
154
Research Site
Saga, Japan, 849-8501
Actively Recruiting
155
Research Site
Sapporo, Japan, 006-8555
Actively Recruiting
156
Research Site
Sendai, Japan, 981-0914
Actively Recruiting
157
Research Site
Suita-shi, Japan, 565-0871
Actively Recruiting
158
Research Site
Tokyo, Japan, 104-0045
Actively Recruiting
159
Research Site
Toyoake-shi, Japan, 470-1192
Actively Recruiting
160
Research Site
Tsu, Japan, 514-8507
Actively Recruiting
161
Research Site
Yokohama, Japan, 232-0024
Actively Recruiting
162
Research Site
Yokohama, Japan, 241-8515
Actively Recruiting
163
Research Site
Amsterdam, Netherlands, 1081HV
Not Yet Recruiting
164
Research Site
Groningen, Netherlands, 9700 RB
Actively Recruiting
165
Research Site
Maastricht, Netherlands, 6229 HX
Actively Recruiting
166
Research Site
Rotterdam, Netherlands, 3015 GD
Not Yet Recruiting
167
Research Site
Utrecht, Netherlands, 3584 CX
Not Yet Recruiting
168
Research Site
Gdansk, Poland, 80-214
Not Yet Recruiting
169
Research Site
Koszalin, Poland, 75-581
Not Yet Recruiting
170
Research Site
Lublin, Poland, 20-090
Not Yet Recruiting
171
Research Site
Olsztyn, Poland, 10-228
Not Yet Recruiting
172
Research Site
Warsaw, Poland, 02-034
Not Yet Recruiting
173
Research Site
Busan, South Korea, 48108
Not Yet Recruiting
174
Research Site
Goyang-si, South Korea, 410-769
Not Yet Recruiting
175
Research Site
Gyeonggi-do, South Korea, 13620
Not Yet Recruiting
176
Research Site
Seongnam-si, South Korea, 463-712
Actively Recruiting
177
Research Site
Seoul, South Korea, 03080
Not Yet Recruiting
178
Research Site
Seoul, South Korea, 03722
Not Yet Recruiting
179
Research Site
Seoul, South Korea, 06351
Not Yet Recruiting
180
Research Site
Seoul, South Korea, 5505
Actively Recruiting
181
Research Site
Barcelona, Spain, 08035
Actively Recruiting
182
Research Site
Barcelona, Spain, 08036
Actively Recruiting
183
Research Site
Madrid, Spain, 28007
Actively Recruiting
184
Research Site
Madrid, Spain, 28027
Actively Recruiting
185
Research Site
Madrid, Spain, 28040
Actively Recruiting
186
Research Site
Santander, Spain, 39008
Actively Recruiting
187
Research Site
Changhua, Taiwan, 500
Actively Recruiting
188
Research Site
Kaohsiung City, Taiwan, 83301
Actively Recruiting
189
Research Site
Taichung, Taiwan, 40447
Actively Recruiting
190
Research Site
Tainan, Taiwan, 70403
Actively Recruiting
191
Research Site
Tainan County, Taiwan, 71044
Actively Recruiting
192
Research Site
Taipei, Taiwan, 10002
Actively Recruiting
193
Research Site
Taipei, Taiwan, 112
Actively Recruiting
194
Research Site
Taoyuan, Taiwan, 333
Actively Recruiting
195
Research Site
Bangkok, Thailand, 10210
Not Yet Recruiting
196
Research Site
Bangkok, Thailand, 10700
Actively Recruiting
197
Research Site
Chiang Mai, Thailand, 50200
Actively Recruiting
198
Research Site
Dusit, Thailand, 10300
Actively Recruiting
199
Research Site
Hat Yai, Thailand, 90110
Actively Recruiting
200
Research Site
Muang, Thailand, 40002
Actively Recruiting
201
Research Site
Ubonratchathani, Thailand, 34000
Not Yet Recruiting
202
Research Site
Altındağ, Turkey (Türkiye), 06230
Actively Recruiting
203
Research Site
Ankara, Turkey (Türkiye), 06530
Actively Recruiting
204
Research Site
Erzurum, Turkey (Türkiye), 25240
Actively Recruiting
205
Research Site
Istanbul, Turkey (Türkiye), 34180
Withdrawn
206
Research Site
Izmir, Turkey (Türkiye), 35100
Actively Recruiting
207
Research Site
Cambridge, United Kingdom, CB2 0QQ
Not Yet Recruiting
208
Research Site
Leeds, United Kingdom, LS9 7TF
Not Yet Recruiting
209
Research Site
London, United Kingdom, NW3 2QG
Not Yet Recruiting
210
Research Site
London, United Kingdom, SE5 9RS
Not Yet Recruiting
211
Research Site
London, United Kingdom, W12 0HS
Actively Recruiting
212
Research Site
Manchester, United Kingdom, M20 4BX
Not Yet Recruiting
213
Research Site
Hanoi, Vietnam, 100000
Actively Recruiting
214
Research Site
Hanoi, Vietnam, 100000
Withdrawn
215
Research Site
Hanoi, Vietnam, 100000
Not Yet Recruiting
216
Research Site
Ho Chi Minh City, Vietnam, 700000
Actively Recruiting
217
Research Site
Ho Chi Minh City, Vietnam, 700000
Not Yet Recruiting
Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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