Actively Recruiting
A Phase III Trial of HRS-1893 in Patients With Obstructive Hypertrophic Cardiomyopathy
Led by Shandong Suncadia Medicine Co., Ltd. · Updated on 2025-08-20
216
Participants Needed
1
Research Sites
63 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study is being conducted to evaluate the efficacy and safety of HRS-1893 for obstructive hypertrophic cardiomyopathy.
CONDITIONS
Official Title
A Phase III Trial of HRS-1893 in Patients With Obstructive Hypertrophic Cardiomyopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 85 years old, any gender
- Body mass index less than 35 kg/m2
- Diagnosed with obstructive hypertrophic cardiomyopathy
- Echocardiography showing Rest LVOT gradient ≥50 mmHg, or Rest LVOT gradient ≥30 mmHg and LVOT gradient ≥50 mmHg after Valsalva maneuver
- Left ventricular ejection fraction of 60% or higher
- New York Heart Association (NYHA) classification grade II or III
- Understand the study procedures, provide written informed consent, and agree to follow the study protocol
You will not qualify if you...
- Known or suspected invasive, genetic, or storage diseases causing cardiac hypertrophy similar to obstructive hypertrophic cardiomyopathy (e.g., Noonan syndrome, Fabry's disease, amyloidosis)
- History of severe valvular heart disease
- Abnormal laboratory test results at screening or other clinically significant abnormal screening values deemed unsuitable by the investigator
- Physical or mental illnesses or conditions increasing trial risk, affecting compliance, or preventing completion of the study as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Beijing, Beijing Municipality, China, 100032
Actively Recruiting
Research Team
Y
Yun Jin
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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