Actively Recruiting
A Phase I/IIa Study of JAB-23E73 in Patients With Advanced Solid Tumors Harboring KRAS Gene Alteration
Led by Jacobio Pharmaceuticals Co., Ltd. · Updated on 2026-01-20
334
Participants Needed
32
Research Sites
144 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multicenter, open-label, phase I/IIa to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of pan-KRAS inhibitor JAB-23E73 in patients with advanced solid tumors harboring KRAS mutations or amplification. The study consists of 2 phases: Phase 1 Dose Escalation and Phase IIa Dose Expansion.
CONDITIONS
Official Title
A Phase I/IIa Study of JAB-23E73 in Patients With Advanced Solid Tumors Harboring KRAS Gene Alteration
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histological or cytological diagnosis of a locally advanced, unresectable, or metastatic solid tumor with KRAS gene alteration (mutation or amplification)
- Ability to provide archived tumor tissue or fresh biopsy sample
- Life expectancy of at least 3 months at treatment start
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- At least one measurable lesion according to RECIST v1.1
- Adequate organ function
You will not qualify if you...
- Unable to swallow oral medications or have gastrointestinal conditions affecting drug absorption
- Previous treatment with rat sarcoma (RAS) targeting agents
- Symptomatic, untreated, or actively progressing central nervous system (CNS) metastases
- Impaired cardiovascular function or significant cardiac disease
- Mean QTcF interval greater than 470 msec
- Females who are pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 32 locations
1
Anhui Provincial Cancer Hospital
Hefei, Anhui, China, 230001
Not Yet Recruiting
2
National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Beijing, Beijing Municipality, China, 100021
Actively Recruiting
3
Beijing Cancer Hospital
Beijing, Beijing Municipality, China, 100032
Actively Recruiting
4
Beijing Chest Hospital
Beijing, Beijing Municipality, China, 100032
Actively Recruiting
5
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100032
Actively Recruiting
6
Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100050
Not Yet Recruiting
7
Fujian cancer Hospital
Fuzhou, Fujian, China, 350014
Not Yet Recruiting
8
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China, 510120
Actively Recruiting
9
Guangxi Medical University Cancer Hospital
Nanning, Guangxi, China, 530012
Actively Recruiting
10
National Cancer Center/Cancer Hospital- Langfang Campus, Chinese Academy of Medical Sciences and Peking Union Medical College
Langfang, Hebei, China, 065000
Actively Recruiting
11
Harbin Medical University Cancer Hospital
Haerbin, Heilongjiang, China, 150081
Actively Recruiting
12
Henan Cancer Hospital
Zhengzhou, Henan, China, 450003
Actively Recruiting
13
The First Affiliated hospital of Zhengzhou University
Zhengzhou, Henan, China, 450052
Actively Recruiting
14
Tongji Hospital
Wuhan, Hubei, China, 430030
Not Yet Recruiting
15
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China, 430071
Actively Recruiting
16
Hunan Cancer Hospital
Changsha, Hunan, China, 200032
Not Yet Recruiting
17
Nanjing Drum Tower Hospital
Nanjing, Jiangsu, China, 210008
Actively Recruiting
18
Jiangsu Cancer Hospital
Nanjing, Jiangsu, China, 210009
Not Yet Recruiting
19
Jiangsu Province Hospital
Nanjing, Jiangsu, China, 210029
Actively Recruiting
20
The First Affiliate of Soochow University
Suzhou, Jiangsu, China, 215006
Not Yet Recruiting
21
The First Affiliated hospital of Nanchang University
Nanchang, Jiangxi, China, 330006
Actively Recruiting
22
The First Hospital of China Medical University
Shenyang, Liaoning, China, 110001
Actively Recruiting
23
Shanghai Jiaotong University School of Medicine Ruijin Hospital
Shanghai, Shanghai Municipality, China, 200025
Not Yet Recruiting
24
Fudan University Zhongshan Hospital
Shanghai, Shanghai Municipality, China, 200032
Not Yet Recruiting
25
Huashan Hospital Fudan University
Shanghai, Shanghai Municipality, China, 200040
Not Yet Recruiting
26
ShanXi Cancer Hospital
Taiyuan, Shanxi, China, 650118
Actively Recruiting
27
The First Affiliated hospital of Xi'an Jiaotong University
Xi’an, Shanxi, China, 710061
Not Yet Recruiting
28
West China Hospital, Sichuan University
Chengdu, Sichuan, China, 610041
Not Yet Recruiting
29
Tianjin Medical University Cancer Institute&Hospital
Tianjin, Tianjin Municipality, China, 300211
Not Yet Recruiting
30
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China, 310005
Actively Recruiting
31
The Second Affiliate Hospital Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310009
Not Yet Recruiting
32
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China, 310014
Not Yet Recruiting
Research Team
J
Jacobio Pharmaceuticals
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here