Actively Recruiting
A Phase II/III Trial Comparing Transarterial Tirapazamine Embolization (TATE) With cTACE for Intermediate-stage Liver Cancer.
Led by Zhejiang Raygene Pharmaceuticals Co., Ltd · Updated on 2025-04-06
300
Participants Needed
2
Research Sites
209 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This phase I/II clinical trial aims to determine the efficacy and safety of TATE compared to TACE in patients with intermediate-stage HCC. The results will provide valuable insights into the potential benefits of TATE as a novel treatment option for HCC.
CONDITIONS
Official Title
A Phase II/III Trial Comparing Transarterial Tirapazamine Embolization (TATE) With cTACE for Intermediate-stage Liver Cancer.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with primary hepatocellular carcinoma according to AASLD criteria
- No evidence of extrahepatic metastasis, regional lymph node involvement, or vascular tumor thrombus
- Eligible for Transarterial Embolization (TAE) or Transarterial Chemoembolization (TACE) treatment
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Child-Pugh score of 7 or less
- Adequate bone marrow, liver, and kidney function
You will not qualify if you...
- History of liver transplantation
- Previous radioembolization or radiotherapy for liver tumors
- Severe cardiovascular or renal diseases
- Active systemic infections
- Clinically significant hypoxia (oxygen saturation below 92% without oxygen supplementation)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Zhongda Hospital, Affiliated to Southeast University
Nanjing, Jiangsu, China, 210009
Actively Recruiting
2
Lishui Central Hospital
Lishui, Zhejiang, China, 323000
Actively Recruiting
Research Team
B
Bill Shen, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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