Actively Recruiting
Phase IV Clinical Study of Sequential Vaccination of Sabin Strain and Wild Strain Inactivated Poliovirus Vaccine
Led by Sinovac Biotech Co., Ltd · Updated on 2026-03-09
480
Participants Needed
3
Research Sites
46 weeks
Total Duration
On this page
Sponsors
S
Sinovac Biotech Co., Ltd
Lead Sponsor
A
Aga Khan University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to compare the immunogenicity and safety of sIPV administered via subcutaneous and intramuscular injection routes
CONDITIONS
Official Title
Phase IV Clinical Study of Sequential Vaccination of Sabin Strain and Wild Strain Inactivated Poliovirus Vaccine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Infants aged 56 to 84 days (2 months old)
- Parent or legal guardian provides written informed consent
- Able to provide vaccination records since birth
- Infant's mother tested negative for HIV, syphilis, hepatitis B, and hepatitis C during or before enrollment (pregnancy test results accepted)
You will not qualify if you...
- History of any polio vaccination
- History of severe allergic reaction to previous vaccinations or vaccine components
- Premature birth before 37 weeks of gestation
- History of asphyxia rescue or nervous system injury
- Congenital malformations, developmental disorders, significant genetic defects, or severe malnutrition
- Autoimmune diseases or immunodeficiency/immunosuppression
- Serious chronic diseases such as Down's syndrome, diabetes, sickle cell anemia, or neurological disorders
- Abnormal blood clotting conditions
- Use of immunosuppressants (except topical or inhaled corticosteroids), cytotoxic drugs, or immunomodulatory therapies
- Received blood products before vaccination
- Use of other study drugs within 30 days before enrollment
- Received live attenuated vaccines within 14 days before enrollment
- Received subunit or inactivated vaccines within 7 days before enrollment
- Acute illness or worsening chronic disease within 7 days before enrollment
- Significant acute diseases, chronic infections, or fever (temperature ≥ 37.5°C) before enrollment
- Any other factors deemed unsuitable by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Centennial Clindev Research and Development of Medical Sciences
Kawit, Cavite, Philippines
Actively Recruiting
2
Iloilo Doctors' Hospital
Iloilo City, Philippines
Actively Recruiting
3
Health Index Multispecialty Clinic - Research and Development on Medical Sciences
Imus, Philippines
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here