Actively Recruiting
Phase 2 - Rhythmic Light Therapy for Alzheimer's Disease Patients
Led by Icahn School of Medicine at Mount Sinai · Updated on 2025-06-05
120
Participants Needed
2
Research Sites
205 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Participants will randomly be placed into one of four groups and experience one of the four following conditions: (1) a placebo light that provides a 40 hertz (Hz) flicker (rhythmic light \[RL\]); (2) a placebo light with a random flicker (placebo condition for rhythmic light); (3) a light source that will stimulate the circadian system and provides a 40 Hz flicker (RL); or (4) a light source that will stimulate the circadian system and provides a random flicker (placebo condition for rhythmic light). Following a baseline week, participants will experience his/her assigned lighting condition for two hours in the morning for 8 weeks. After a 4-week washout period, a final round of assessments will be obtained. Study assessments (except for the Pittsburgh Sleep Quality Index and Montreal Cognitive Assessment) will be collected at the end of each week, for a total of 8 assessments.
CONDITIONS
Official Title
Phase 2 - Rhythmic Light Therapy for Alzheimer's Disease Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with mild cognitive impairment or mild Alzheimer's disease with a Montreal Cognitive Assessment score between 17 and 25
- Have sleep disturbance indicated by a Pittsburgh Sleep Quality Index score greater than 5
- Reside in their home, independent living, or assisted living facilities
You will not qualify if you...
- Taking sleep medication
- Living in a skilled nursing facility or long-term care
- Have obstructing cataracts, macular degeneration, or blindness
- Have severe sleep apnea or restless leg syndrome
- Have a history of severe epilepsy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Light and Health Research Center
Menands, New York, United States, 12204
Actively Recruiting
2
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Actively Recruiting
Research Team
B
Barbara Plitnick, BSN
CONTACT
M
Mariana Figueiro, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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