Actively Recruiting
Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors
Led by Xencor, Inc. · Updated on 2026-03-17
282
Participants Needed
16
Research Sites
243 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary purpose of this study is to determine whether the investigational drug XmAb541 is safe and well tolerated, and to determine an optimal and safe dose(s) for further study. The study will also evaluate the effect of XmAb541 on tumor outcomes.
CONDITIONS
Official Title
Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older; for germ cell tumor patients, age 15 years or older
- Tumor tests positive for CLDN6
- Histological or cytological confirmation of locally advanced, recurrent, or metastatic ovarian, fallopian tube, or peritoneal cancer; adenocarcinoma of the endometrium; or treatment-resistant germ cell tumor
- Adequate Eastern Cooperative Oncology Group performance status
- Life expectancy of at least 3 months
- Adequate liver, kidney, and bone marrow function
You will not qualify if you...
- Active known or suspected autoimmune disease
- Use of systemic corticosteroids, prednisone equivalents, or other immunosuppressive medications within 14 days before first dose
- Clinically significant cardiovascular, pulmonary, or gastrointestinal disease
- Active hepatitis B or hepatitis C
- Patients with treated brain metastases may participate only if radiologically stable
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 16 locations
1
City of Hope
Duarte, California, United States, 91010
Not Yet Recruiting
2
Stanford
Palo Alto, California, United States, 94304
Not Yet Recruiting
3
University of California
San Francisco, California, United States, 94158
Actively Recruiting
4
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Actively Recruiting
5
Winship Cancer Institute, Emory University
Atlanta, Georgia, United States, 30322
Actively Recruiting
6
University of Chicago Medical Center
Chicago, Illinois, United States, 60637
Actively Recruiting
7
Indian University Melvin and Bren Simon Comprehensive Cancer Center
Indianapolis, Indiana, United States, 46202
Actively Recruiting
8
Karmanos Cancer Institute
Detroit, Michigan, United States, 48201
Actively Recruiting
9
The John Theruer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Actively Recruiting
10
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Actively Recruiting
11
Montefiore Einstein Comprehensive Cancer Center
The Bronx, New York, United States, 10461
Actively Recruiting
12
The Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
13
OU Health Stephenson Cancer Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
14
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
15
SCRI Oncology Partners
Nashville, Tennessee, United States, 37203
Actively Recruiting
16
University of Virginia
Charlottesville, Virginia, United States, 22903
Actively Recruiting
Research Team
G
Gabrielle Golden
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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