Actively Recruiting

Phase 2
Age: 18Years +
All Genders
NCT06989359

Phase 2 Study of ADX-038 in Complement-Mediated Kidney Disease

Led by ADARx Pharmaceuticals, Inc. · Updated on 2026-04-22

45

Participants Needed

25

Research Sites

196 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This Phase 2 study is designed to assess the safety, efficacy, pharmacokinetics (PK) and pharmacodynamics (PD) of ADX-038 in adults with complement-mediated kidney diseases.

CONDITIONS

Official Title

Phase 2 Study of ADX-038 in Complement-Mediated Kidney Disease

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Mean eGFR greater than or equal to 30 mL/min/1.73m2
  • Clinical evidence of active kidney disease
  • Treated with supportive care including an ACE inhibitor or ARB if applicable
  • Willing to receive required vaccinations
  • Primary diagnosis of IgAN, C3G or IC-MPGN confirmed by a kidney biopsy
Not Eligible

You will not qualify if you...

  • Hereditary or acquired complement deficiency
  • Kidney transplant or renal replacement therapy
  • History of solid organ transplant
  • Other kidney disease
  • History of recurrent invasive infections
  • Received complement inhibitor treatments
  • Active systemic viral, bacterial, or fungal infection
  • Abnormal liver function

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 25 locations

1

ADARx Clinical Site

Doral, Florida, United States, 33122

Actively Recruiting

2

ADARx Clinical Site

Miami, Florida, United States, 33127

Actively Recruiting

3

ADARx Clinical Site

Pembroke Pines, Florida, United States, 33029

Actively Recruiting

4

ADARx Clinical Site

Iowa City, Iowa, United States, 52242

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5

ADARx Clinical Site

Shreveport, Louisiana, United States, 71101

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6

ADARx Clinical Site

Shelby, Michigan, United States, 48315

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7

ADARx Clinical Site

Great Neck, New York, United States, 11021

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8

ADARx Clinical Site

Columbus, Ohio, United States, 43210

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9

ADARx Clinical Site

Dakota Dunes, South Dakota, United States, 57049

Actively Recruiting

10

ADARx Clinical Site

Dallas, Texas, United States, 75230

Actively Recruiting

11

ADARx Clinical Site

Houston, Texas, United States, 77027

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12

ADARx Clinical Site

Wollongong, New South Wales, Australia, 2500

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13

ADARx Clinical Site

Sydney, Australia, NSW 2139

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14

ADARx Clinical Site

Woolloongabba, Australia, QLD 4102

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15

ADARx Clinical Site

Hong Kong, Hong Kong, 2500

Actively Recruiting

16

ADARx Clinical Site

Shatin, Hong Kong

Actively Recruiting

17

ADARx Clinical Site

Cheonan, South Korea, 31151

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18

ADARx Clinical Site

Daegu, South Korea, 42601

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19

ADARx Clinical Site

Gyeonggi-do, South Korea, 05278

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20

ADARx Clinical Site

Seoul, South Korea, 02841

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21

ADARx Clinical Site

Seoul, South Korea, 03080

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22

ADARx Clinical Site

Seoul, South Korea, 03722

Actively Recruiting

23

ADARx Clinical Site

Seoul, South Korea, 05278

Actively Recruiting

24

ADARx Clinical Site

Madrid, Spain, 28041

Actively Recruiting

25

ADARx Clinical Site

Newcastle upon Tyne, United Kingdom, UK, NE7 7DN

Actively Recruiting

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Research Team

L

Lyle Gee

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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