Actively Recruiting
A Phase 2 Study of Anvumetostat in Participants With MTAP-deleted Advanced NSCLC (MTAPESTRY 201)
Led by Amgen · Updated on 2026-04-07
200
Participants Needed
91
Research Sites
309 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main objective of the study is to characterize safety and efficacy of 2 dose levels of anvumetostat by investigator, and to evaluate anvumetostat monotherapy efficacy by Blinded Independent Central Review (BICR).
CONDITIONS
Official Title
A Phase 2 Study of Anvumetostat in Participants With MTAP-deleted Advanced NSCLC (MTAPESTRY 201)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically or cytologically confirmed metastatic or unresectable locally advanced MTAP-deleted NSCLC
- Received and progressed or recurred after at least 1 prior systemic therapy for advanced or metastatic disease
- Availability of an archival tissue sample or block
- Life expectancy greater than 3 months as judged by the investigator
- Participants with treated brain metastases with radiation or surgery at least 14 days before study start
- Participants with untreated asymptomatic brain metastases 2 cm or smaller per lesion without need for corticosteroids
You will not qualify if you...
- Tumors with mutations treatable by targeted therapies including EGFR, ALK, ROS1, NTRK, MET, BRAF, RET, HER2/ERBB2, KRAS G12C
- Major surgery within 28 days before study start
- Untreated symptomatic central nervous system metastatic disease of any size
- Asymptomatic brain metastases larger than 2 cm per lesion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 91 locations
1
City of Hope National Medical Center
Duarte, California, United States, 91010
Actively Recruiting
2
City of Hope Orange County Lennar Foundation Cancer Center
Duarte, California, United States, 91010
Actively Recruiting
3
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
4
Valkyrie Clinical Trials
Los Angeles, California, United States, 90067
Actively Recruiting
5
University of California Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
6
Rocky Mountain Cancer Centers
Denver, Colorado, United States, 80218
Actively Recruiting
7
Eastern Connecticut Hematology and Oncology Associates
Norwich, Connecticut, United States, 06360
Actively Recruiting
8
Hartford HealthCare Cancer Institute - Manchester
Plainville, Connecticut, United States, 06062
Actively Recruiting
9
Medstar Georgetown University Hospital
Washington D.C., District of Columbia, United States, 20007
Actively Recruiting
10
Our Lady of the Lake Cancer Institute
Baton Rouge, Louisiana, United States, 70808
Actively Recruiting
11
Trinity Health Saint Joseph Mercy Ann Arbor
Ann Arbor, Michigan, United States, 48106
Actively Recruiting
12
Cancer and Hematology Centers of Western Michigan
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
13
Sarah Cannon Research Institute Oncology Partners
Nashville, Tennessee, United States, 37203
Actively Recruiting
14
United States Oncology Regulatory Affairs Corporate Office
Nashville, Tennessee, United States, 37203
Actively Recruiting
15
Texas Oncology Central/South Texas
Austin, Texas, United States, 78745
Actively Recruiting
16
Sarah Cannon Research Institute
Dallas, Texas, United States, 75230
Actively Recruiting
17
Texas Oncology - Dallas Fort Worth
Dallas, Texas, United States, 75246
Actively Recruiting
18
US Oncology Research Investigational Products Center
Irving, Texas, United States, 75063
Actively Recruiting
19
Texas Oncology Northeast Texas
Tyler, Texas, United States, 75702
Actively Recruiting
20
Virginia Cancer Specialists PC
Fairfax, Virginia, United States, 22031
Actively Recruiting
21
GenesisCare -North Shore Oncology
St Leonards, New South Wales, Australia, 2065
Actively Recruiting
22
Calvary Mater Newcastle Hospital
Waratah, New South Wales, Australia, 2298
Actively Recruiting
23
Mater Hospital Brisbane
South Brisbane, Queensland, Australia, 4101
Actively Recruiting
24
Cancer Research South Australia
Adelaide, South Australia, Australia, 5000
Actively Recruiting
25
Núcleo de Oncologia da Bahia
Salvador, Estado de Bahia, Brazil, 40170-110
Actively Recruiting
26
Liga Norte-Riograndense Contra O Cancer
Natal, Rio Grande do Norte, Brazil, 59062-000
Actively Recruiting
27
Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
Porto Alegre, Rio Grande do Sul, Brazil, 90610-000
Actively Recruiting
28
Hospital Nossa Senhora da Conceicao
Porto Alegre, Rio Grande do Sul, Brazil, 91010-004
Actively Recruiting
29
Fundacao pio xII Barretos
Barretos, São Paulo, Brazil, 14784-400
Actively Recruiting
30
Fund Faculdade Regional Med Sao Jose Rio Preto
São José do Rio Preto, São Paulo, Brazil, 15090-000
Actively Recruiting
31
Instituto do Cancer Estado SP Icesp
São Paulo, São Paulo, Brazil, 01246-000
Actively Recruiting
32
Fundacao Antonio Prudente - Hosp AC Camargo
São Paulo, São Paulo, Brazil, 01509-900
Actively Recruiting
33
Instituto de Educacao Pesquisa e Gestao em Saude
Rio de Janeiro, Brazil, 22775-001
Actively Recruiting
34
Centro Paulista de Oncologia
São Paulo, Brazil, 04538-132
Actively Recruiting
35
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Actively Recruiting
36
William Osler Health System - Brampton Civic Hospital
Brampton, Ontario, Canada, L6R 3J7
Actively Recruiting
37
London Health Sciences Centre
London, Ontario, Canada, N6A 4L6
Actively Recruiting
38
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
39
McGill University Health Centre Glen Site
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
40
Beijing Cancer Hospital
Beijing, Beijing Municipality, China, 100142
Actively Recruiting
41
Mengchao Hepatobiliary Hospital of Fujian Medical University
Fuzhou, Fujian, China, 350028
Actively Recruiting
42
Henan Cancer Hospital
Zhengzhou, Henan, China, 450001
Actively Recruiting
43
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450052
Actively Recruiting
44
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, China, 430022
Actively Recruiting
45
The Second Xiangya Hospital of Central South University
Changsha, Hunan, China, 410011
Actively Recruiting
46
Jilin Cancer Hospital
Changchun, Jilin, China, 130012
Actively Recruiting
47
Jinan Central Hospital
Jinan, Shandong, China, 250013
Actively Recruiting
48
Shanghai East Hospital
Shanghai, Shanghai Municipality, China, 200123
Actively Recruiting
49
West China Hospital Sichuan University
Chengdu, Sichuan, China, 610041
Actively Recruiting
50
The First Affiliated Hospital Zhejiang University School Of Medicine
Hangzhou, Zhejiang, China, 310003
Actively Recruiting
51
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China, 310005
Actively Recruiting
52
Beijing Cancer Hospital
Beijing, China, 100142
Actively Recruiting
53
Beijing Chest Hospital, Capital Medical University
Beijing, China, 101149
Actively Recruiting
54
Masarykuv onkologicky ustav
Brno, Czechia, 656 53
Actively Recruiting
55
Fakultni nemocnice Olomouc
Olomouc, Czechia, 779 00
Actively Recruiting
56
Vseobecna fakultni nemocnice v Praze
Prague, Czechia, 128 08
Actively Recruiting
57
Fakultni Thomayerova nemocnice
Prague, Czechia, 140 59
Actively Recruiting
58
Queen Mary Hospital, The University of Hong Kong
Hong Kong, Hong Kong
Actively Recruiting
59
Prince of Wales Hospital, Chinese University of Hong Kong
Shatin, New Territories, Hong Kong
Actively Recruiting
60
Aichi Cancer Center
Nagoya, Aichi-ken, Japan, 464-8681
Actively Recruiting
61
National Cancer Center Hospital East
Kashiwa-shi, Chiba, Japan, 277-8577
Actively Recruiting
62
Shizuoka Cancer Center
Sunto-gun, Shizuoka, Japan, 411-8777
Actively Recruiting
63
National Cancer Center Hospital
Chuo-ku, Tokyo, Japan, 104-0045
Actively Recruiting
64
The Cancer Institute Hospital of Japanese Foundation for Cancer Research
Koto-ku, Tokyo, Japan, 135-8550
Actively Recruiting
65
Wakayama Medical University Hospital
Wakayama, Wakayama, Japan, 641-8510
Actively Recruiting
66
Pauls Stradins Clinical University Hospital
Riga, Latvia, 1002
Actively Recruiting
67
Riga East Clinical University Hospital
Riga, Latvia, 1079
Actively Recruiting
68
Nederlands Kanker Instituut Antoni van Leeuwenhoekziekenhuis
Amsterdam, Netherlands, 1066 CX
Actively Recruiting
69
Sint Jansdal Ziekenhuis
Harderwijk, Netherlands, 3844 DG
Actively Recruiting
70
Erasmus Medisch Centrum
Rotterdam, Netherlands, 3015 GD
Actively Recruiting
71
Unidade Local de Saude de Braga, EPE
Braga, Portugal, 4710-243
Actively Recruiting
72
Fundacao Champalimaud
Lisbon, Portugal, 1400-038
Actively Recruiting
73
Hospital Cuf porto
Porto, Portugal, 4100-180
Actively Recruiting
74
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE
Porto, Portugal, 4200-072
Actively Recruiting
75
National University Hospital
Singapore, Singapore, 119074
Actively Recruiting
76
National Cancer Centre Singapore
Singapore, Singapore, 168583
Actively Recruiting
77
Cha Bundang Medical Center, Cha University
Seongnam-si, Gyeonggi-do, South Korea, 13496
Actively Recruiting
78
Severance Hospital Yonsei University Health System
Seoul, South Korea, 03722
Actively Recruiting
79
Ajou University Hospital
Suwon-si Gyeonggi-do, South Korea, 16499
Actively Recruiting
80
The Catholic University of Korea St Vincents Hospital
Suwon-si, Gyeonggi-do, South Korea, 16247
Actively Recruiting
81
Universitaetsspital Basel
Basel, Switzerland, 4031
Actively Recruiting
82
Hopitaux Universitaires de Geneve
Geneva, Switzerland, 1211
Actively Recruiting
83
Kantonsspital Sankt Gallen
Sankt Gallen, Switzerland, 9007
Actively Recruiting
84
Taichung Veterans General Hospital
Taichung, Taiwan, 40705
Actively Recruiting
85
National Cheng Kung University Hospital
Tainan, Taiwan, 70403
Actively Recruiting
86
National Taiwan University Hospital
Taipei, Taiwan, 10002
Actively Recruiting
87
Adana Sehir Egitim ve Arastirma Hastanesi
Adana, Turkey (Türkiye), 01370
Actively Recruiting
88
Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi Gazi Hastanesi
Ankara, Turkey (Türkiye), 06560
Actively Recruiting
89
Ankara Bilkent Sehir Hastanesi
Ankara, Turkey (Türkiye), 06800
Actively Recruiting
90
Memorial Bahcelievler Hastanesi
Istanbul, Turkey (Türkiye), 34180
Actively Recruiting
91
Bagcilar Medipol Mega Universite Hastanesi
Istanbul, Turkey (Türkiye), 34214
Actively Recruiting
Research Team
A
Amgen Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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