Actively Recruiting

Phase 3
Age: 12Years - 100Years
All Genders
NCT06840392

A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa

Led by Novartis Pharmaceuticals · Updated on 2026-03-11

555

Participants Needed

138

Research Sites

150 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this study is to establish the efficacy, safety, and tolerability of remibrutinib (LOU064) Dose A and Dose B compared to placebo in participants with moderate to severe hidradenitis suppurativa (HS).

CONDITIONS

Official Title

A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa

Who Can Participate

Age: 12Years - 100Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Male and female participants 12 years of age or older at the time of informed consent
  • Diagnosis of hidradenitis suppurativa based on clinical history and physical exam for at least 6 months before baseline
  • Moderate to severe hidradenitis suppurativa defined by at least 5 abscesses and/or inflammatory nodules
  • Inflammatory lesions affecting at least 2 distinct anatomic areas (e.g., left and right armpits)
Not Eligible

You will not qualify if you...

  • More than 20 fistulae or tunnels (draining or non-draining) at baseline
  • Any active skin disease or condition interfering with hidradenitis suppurativa assessment
  • Previous use of remibrutinib or other BTK inhibitors
  • Use of other investigational drugs within 5 half-lives, 30 days, or until pharmacodynamics return to baseline prior to randomization
  • Significant bleeding risk or coagulation disorders
  • History of gastrointestinal bleeding
  • Need for anti-platelet (except low-dose aspirin or clopidogrel) or anti-coagulant medication
  • History or current liver disease
  • Major surgery within 8 weeks before screening or planned during the study
  • History of hypersensitivity to any study drug components
  • Known or suspected active, chronic, or recurrent infectious diseases (e.g., tuberculosis, HIV)
  • History of live attenuated vaccine within 6 weeks before randomization or need for such vaccines during treatment
  • Any clinically significant cardiovascular, neurological, psychiatric, pulmonary, renal, endocrine, metabolic, hematological, gastrointestinal, or immunodeficiency condition that could affect safety or study results

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 138 locations

1

Total Skin and Beauty Dermatology Center PC

Birmingham, Alabama, United States, 35205

Actively Recruiting

2

CTT Research

Gilbert, Arizona, United States, 85234

Actively Recruiting

3

Ctr Dermatology and Plastic Surgery

Scottsdale, Arizona, United States, 85260

Actively Recruiting

4

Ctr for Dermatology Clinical Res

Fremont, California, United States, 95438

Actively Recruiting

5

USC Keck School of Medicine

Los Angeles, California, United States, 90033

Actively Recruiting

6

MedDerm Associates

San Diego, California, United States, 92103

Actively Recruiting

7

Driven Research

Coral Gables, Florida, United States, 33134

Actively Recruiting

8

Floridian Research Institute

Miami, Florida, United States, 33179

Actively Recruiting

9

Sarasota Arthritis Res Ctr

Sarasota, Florida, United States, 34239

Actively Recruiting

10

University Of South Florida

Tampa, Florida, United States, 33612

Actively Recruiting

11

Emory School of Med Dermatology

Atlanta, Georgia, United States, 30303

Actively Recruiting

12

Atlanta Biomedical Clin Res LLC

Atlanta, Georgia, United States, 30331

Actively Recruiting

13

Northwestern University

Chicago, Illinois, United States, 60611

Actively Recruiting

14

Endeavor Health

Glenview, Illinois, United States, 60077

Actively Recruiting

15

Dundee Dermatology

West Dundee, Illinois, United States, 60118

Actively Recruiting

16

Southern IN Clinical Trials

New Albany, Indiana, United States, 47150

Actively Recruiting

17

Beth Israel Deaconess Med Center

Boston, Massachusetts, United States, 02215

Actively Recruiting

18

Metro Boston Clinical Partners

Brighton, Massachusetts, United States, 02135

Actively Recruiting

19

Clinical Research Inst of MI

Chesterfield, Michigan, United States, 48047

Actively Recruiting

20

Deluxe Dermatology

St Louis, Missouri, United States, 63117

Actively Recruiting

21

Skin Specialists PC

Omaha, Nebraska, United States, 68144

Actively Recruiting

22

Vivida Dermatology

Las Vegas, Nevada, United States, 89119

Actively Recruiting

23

North Shore University Hospital

New Hyde Park, New York, United States, 11040

Actively Recruiting

24

Cameron Dermatology

New York, New York, United States, 10023

Actively Recruiting

25

Optima Research Boardman

Boardman, Ohio, United States, 44512

Actively Recruiting

26

Ohio State University

Columbus, Ohio, United States, 43210

Actively Recruiting

27

Wright State University

Fairborn, Ohio, United States, 45324

Actively Recruiting

28

Apex Clinical Research Center LLC

Mayfield Heights, Ohio, United States, 44124

Actively Recruiting

29

Clinical Research Ctr of Carolinas

Charleston, South Carolina, United States, 29407

Actively Recruiting

30

Goodlettsville Dermatology Research

Goodlettsville, Tennessee, United States, 37072-2301

Actively Recruiting

31

Accurate Clinical Research

Humble, Texas, United States, 77346

Actively Recruiting

32

Austin Inst for Clinical Research

Pflugerville, Texas, United States, 78660

Actively Recruiting

33

Center for Clinical Studies-Lee

Webster, Texas, United States, 77598

Actively Recruiting

34

Care Access Alexandria

Arlington, Virginia, United States, 22206

Actively Recruiting

35

Complexions Dermatology

Danville, Virginia, United States, 24541

Actively Recruiting

36

Forefront Dermatology

Vienna, Virginia, United States, 22182

Actively Recruiting

37

Novartis Investigative Site

Berazategui, Buenos Aires, Argentina, B1837AVT

Actively Recruiting

38

Novartis Investigative Site

CABA, Argentina, C1012AAY

Actively Recruiting

39

Novartis Investigative Site

Caba, Argentina, C1205AAO

Actively Recruiting

40

Novartis Investigative Site

Córdoba, Argentina, B5000

Actively Recruiting

41

Novartis Investigative Site

Linz, Austria, 4020

Actively Recruiting

42

Novartis Investigative Site

Brussels, Brussels Capital, Belgium, 1070

Actively Recruiting

43

Novartis Investigative Site

Woluwe-Saint-Lambert, Brussels Capital, Belgium, B 1200

Actively Recruiting

44

Novartis Investigative Site

Leuven, Vlaams Brabant, Belgium, 3000

Actively Recruiting

45

Novartis Investigative Site

Liège, Belgium, 4000

Actively Recruiting

46

Novartis Investigative Site

Edmonton, Alberta, Canada, T6G 1C3

Active, Not Recruiting

47

Novartis Investigative Site

London, Ontario, Canada, N6H 5L5

Actively Recruiting

48

Novartis Investigative Site

Montreal, Quebec, Canada, H1Y 3L1

Actively Recruiting

49

Novartis Investigative Site

Québec, Quebec, Canada, G1V 4T3

Actively Recruiting

50

Novartis Investigative Site

Sherbrooke, Quebec, Canada, J1G 1X9

Actively Recruiting

51

Novartis Investigative Site

Medellín, Antioquia, Colombia, 050010

Actively Recruiting

52

Novartis Investigative Site

Bogota, Cundinamarca, Colombia, 110221

Actively Recruiting

53

Novartis Investigative Site

Bogota, Cundinamarca, Colombia, 111411

Actively Recruiting

54

Novartis Investigative Site

Medellín, Colombia, 050012

Actively Recruiting

55

Novartis Investigative Site

Karlovy Vary, Czechia, 360 01

Actively Recruiting

56

Novartis Investigative Site

Plzen Bolevec, Czechia, 32300

Actively Recruiting

57

Novartis Investigative Site

Prague, Czechia, 100 34

Actively Recruiting

58

Novartis Investigative Site

Prague, Czechia, 128 08

Actively Recruiting

59

Novartis Investigative Site

Prague, Czechia, 150 00

Actively Recruiting

60

Novartis Investigative Site

Prague, Czechia, 150 06

Actively Recruiting

61

Novartis Investigative Site

Prague, Czechia, 180 81

Actively Recruiting

62

Novartis Investigative Site

Brest, France, 29609

Actively Recruiting

63

Novartis Investigative Site

La Rochelle, France, 17019

Actively Recruiting

64

Novartis Investigative Site

Lyon, France, 69003

Actively Recruiting

65

Novartis Investigative Site

Nice, France, 06000

Actively Recruiting

66

Novartis Investigative Site

Reims, France, 51100

Actively Recruiting

67

Novartis Investigative Site

Rouen, France, 76031

Actively Recruiting

68

Novartis Investigative Site

Toulouse, France, 31400

Actively Recruiting

69

Novartis Investigative Site

Freiburg im Breisgau, Baden-Wurttemberg, Germany, 79106

Actively Recruiting

70

Novartis Investigative Site

Würzburg, Bavaria, Germany, 97080

Actively Recruiting

71

Novartis Investigative Site

Frankfurt am Main, Hesse, Germany, 60590

Actively Recruiting

72

Novartis Investigative Site

Düsseldorf, North Rhine-Westphalia, Germany, 40225

Actively Recruiting

73

Novartis Investigative Site

Merzig, Saarland, Germany, 66663

Actively Recruiting

74

Novartis Investigative Site

Leipzig, Saxony, Germany, 04103

Actively Recruiting

75

Novartis Investigative Site

Bad Bentheim, Germany, 48455

Actively Recruiting

76

Novartis Investigative Site

Berlin, Germany, 13595

Actively Recruiting

77

Novartis Investigative Site

Dessau, Germany, 06847

Actively Recruiting

78

Novartis Investigative Site

Dortmund, Germany, 44137

Actively Recruiting

79

Novartis Investigative Site

Essen, Germany, 45147

Actively Recruiting

80

Novartis Investigative Site

Hamburg, Germany, 20246

Actively Recruiting

81

Novartis Investigative Site

Lübeck, Germany, 23538

Actively Recruiting

82

Novartis Investigative Site

Minden, Germany, 32429

Actively Recruiting

83

Novartis Investigative Site

München, Germany, 80377

Actively Recruiting

84

Novartis Investigative Site

Tübingen, Germany, 72076

Actively Recruiting

85

Novartis Investigative Site

Athens, Greece, 161 21

Actively Recruiting

86

Novartis Investigative Site

Chaïdári, Greece, 124 62

Actively Recruiting

87

Novartis Investigative Site

Thessaloniki, Greece, 564 03

Actively Recruiting

88

Novartis Investigative Site

Pécs, Baranya, Hungary, 7623

Actively Recruiting

89

Novartis Investigative Site

Debrecen, Hajdu Bihar Megye, Hungary, 4032

Actively Recruiting

90

Novartis Investigative Site

Debrecen, Hajdú-Bihar, Hungary, 4031

Actively Recruiting

91

Novartis Investigative Site

Budapest, Hungary, 1036

Actively Recruiting

92

Novartis Investigative Site

Budapest, Hungary, H-1083

Actively Recruiting

93

Novartis Investigative Site

Kecskemét, Hungary, 6001

Actively Recruiting

94

Novartis Investigative Site

Szeged, Hungary, 6725

Actively Recruiting

95

Novartis Investigative Site

Kuala Lumpur, Kuala Lumpur, Malaysia, 50586

Actively Recruiting

96

Novartis Investigative Site

Ipoh, Perak, Malaysia, 30450

Actively Recruiting

97

Novartis Investigative Site

Kota Kinabalu, Sabah, Malaysia, 88586

Actively Recruiting

98

Novartis Investigative Site

Johor Bahru, Malaysia, 80100

Actively Recruiting

99

Novartis Investigative Site

Selangor Darul Ehsan, Malaysia, 68100

Actively Recruiting

100

Novartis Investigative Site

Wilayah Persekutuan, Malaysia, 62502

Actively Recruiting

101

Novartis Investigative Site

Monterrey, Nuevo León, Mexico, 64460

Actively Recruiting

102

Novartis Investigative Site

Culiacán, Sinaloa, Mexico, 80020

Actively Recruiting

103

Novartis Investigative Site

Durango, Mexico, 34000

Actively Recruiting

104

Novartis Investigative Site

Warsaw, Masovian Voivodeship, Poland, 02-953

Actively Recruiting

105

Novartis Investigative Site

Warsaw, Poland, 02-507

Actively Recruiting

106

Novartis Investigative Site

Warsaw, Poland, 02-962

Actively Recruiting

107

Alma Cruz-Santana Private Practice

Carolina, Puerto Rico, 00985

Actively Recruiting

108

Novartis Investigative Site

Bucharest, District 2, Romania, 020125

Actively Recruiting

109

Novartis Investigative Site

Bucharest, District 2, Romania, 020762

Actively Recruiting

110

Novartis Investigative Site

Bucharest, Romania, 010825

Actively Recruiting

111

Novartis Investigative Site

Timișoara, Romania, 300188

Actively Recruiting

112

Novartis Investigative Site

Granada, Andalusia, Spain, 18014

Actively Recruiting

113

Novartis Investigative Site

Palma, Balearic Islands, Spain, 07120

Actively Recruiting

114

Novartis Investigative Site

Barcelona, Spain, 08041

Actively Recruiting

115

Novartis Investigative Site

Granollers, Spain, 08402

Actively Recruiting

116

Novartis Investigative Site

Las Palmas GC, Spain, 35010

Actively Recruiting

117

Novartis Investigative Site

Madrid, Spain, 28002

Actively Recruiting

118

Novartis Investigative Site

Madrid, Spain, 28041

Actively Recruiting

119

Novartis Investigative Site

Pontevedra, Spain, 36003

Actively Recruiting

120

Novartis Investigative Site

Seville, Spain, 41009

Actively Recruiting

121

Novartis Investigative Site

Valencia, Spain, 46026

Actively Recruiting

122

Novartis Investigative Site

Izmir, Balcova, Turkey (Türkiye), 35340

Actively Recruiting

123

Novartis Investigative Site

Ankara, Bilkent-Cankaya, Turkey (Türkiye), 06800

Actively Recruiting

124

Novartis Investigative Site

Izmir, Buca, Turkey (Türkiye), 35390

Actively Recruiting

125

Novartis Investigative Site

Aydin, Efeler, Turkey (Türkiye), 09100

Actively Recruiting

126

Novartis Investigative Site

Denizli, Kinikli, Turkey (Türkiye), 20070

Actively Recruiting

127

Novartis Investigative Site

Ankara, Sihhiye-Altindag, Turkey (Türkiye), 06230

Actively Recruiting

128

Novartis Investigative Site

Ankara, Yenimahalle, Turkey (Türkiye), 06500

Actively Recruiting

129

Novartis Investigative Site

Mersin, Yenisehir, Turkey (Türkiye), 33110

Actively Recruiting

130

Novartis Investigative Site

Izmir, Turkey (Türkiye), 35100

Actively Recruiting

131

Novartis Investigative Site

Kecioren Ankara, Turkey (Türkiye), 06010

Actively Recruiting

132

Novartis Investigative Site

Leeds, West Yorkshire, United Kingdom, LS7 4SA

Actively Recruiting

133

Novartis Investigative Site

Bristol, United Kingdom, BS1 3NU

Actively Recruiting

134

Novartis Investigative Site

Cardiff, United Kingdom, CF14 4XW

Actively Recruiting

135

Novartis Investigative Site

London, United Kingdom, E1 2AT

Actively Recruiting

136

Novartis Investigative Site

London, United Kingdom, SE1 9RT

Actively Recruiting

137

Novartis Investigative Site

London, United Kingdom, SE5 9RS

Actively Recruiting

138

Novartis Investigative Site

Southampton, United Kingdom, SO16 6YD

Actively Recruiting

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Research Team

N

Novartis Pharmaceuticals

CONTACT

N

Novartis Pharmaceuticals

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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