Actively Recruiting
A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors
Led by Bristol-Myers Squibb · Updated on 2026-04-21
234
Participants Needed
21
Research Sites
175 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to assess BMS-986500 as monotherapy in advanced solid tumors and as combination therapy in CDK4/6 inhibitor pre-treated advanced breast cancer.
CONDITIONS
Official Title
A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must be 18 years of age or older.
- Participants must have histologically confirmed locally advanced, unresectable, or metastatic solid tumor malignancy.
- Participants must have measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) v1.1.
- Participants must have a stable Eastern Cooperative Oncology Group Performance Status of 0 or 1.
- For Part 2A only, participants must have CCNE1-amplified ovarian cancer.
You will not qualify if you...
- Participants must not have active brain metastasis.
- Participants must not have impaired cardiac function or clinically significant cardiac disease.
- Participants must not have bleeding disorder or history of clinically significant bleeding within the prior 3 months.
- Participants must not have Grade 2 or higher peripheral neuropathy.
- Other protocol-defined inclusion and exclusion criteria apply.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 21 locations
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294-3300
Actively Recruiting
2
Providence St. Jude Medical Center
Fullerton, California, United States, 92835
Actively Recruiting
3
Marin Cancer Care
Greenbrae, California, United States, 94904
Actively Recruiting
4
Moores Cancer Center
La Jolla, California, United States, 92093
Actively Recruiting
5
Hoag Memorial Hospital Presbyterian
Newport Beach, California, United States, 92663
Actively Recruiting
6
Local Institution - 0008
Aurora, Colorado, United States, 80045
Not Yet Recruiting
7
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
8
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
9
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
10
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263
Actively Recruiting
11
Northwell Health-Cancer Institute
New Hyde Park, New York, United States, 11042
Actively Recruiting
12
Local Institution - 0011
New York, New York, United States, 10016
Not Yet Recruiting
13
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
14
START Dallas Fort Worth
Fort Worth, Texas, United States, 76104
Actively Recruiting
15
NEXT Oncology
San Antonio, Texas, United States, 78229
Actively Recruiting
16
Odense Universitetshospital
Odense, Region Syddanmark, Denmark, 5000
Actively Recruiting
17
Local Institution - 0025
Copenhagen, Denmark, 2100
Not Yet Recruiting
18
National Cancer Center Hospital East
Kashiwa, Chiba, Japan, 277-8577
Actively Recruiting
19
Kansai Medical University Hospital
Hirakata, Osaka, Japan, 573-1191
Actively Recruiting
20
National Cancer Center Hospital
Chuo-ku, Tokyo, Japan, 104-0045
Actively Recruiting
21
The Cancer Institute Hospital of JFCR
Koto-ku, Tokyo, Japan, 135-8550
Actively Recruiting
Research Team
B
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com, www.BMSStudyConnect.com
CONTACT
F
First line of the email MUST contain NCT # and Site #.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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